Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.82 |
| ▸ | GRM6 | O15303 | 2/20 | 0.82 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.82 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.82 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.82 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.82 |
| ▸ | GSR | P00390 | 1/20 | 0.82 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.82 |
| ▸ | GRM5 | P41594 | 1/20 | 0.82 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.82 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.82 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.82 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.82 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.82 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.82 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.82 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.82 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.82 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL28725412 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL787628 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL787900 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4CYP1A2 | |
| Glutamic Acid SCHEMBL381869 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4CYP1A2 | |
| Glutamic Acid SCHEMBL184513 | 0.98 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 | |
| Glutamic Acid SCHEMBL2803034 | 0.98 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL15797537 | 0.98 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL184512 | 0.98 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL28509459 | 0.98 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL28330083 | 0.98 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12409109-B2 | Dry mixture and personal care composition as well as methods for their production | WEIDMANN HOLDING AG (CH) | 2025-09-09 | — | — | US | disclosed |
| US-20240382389-A1 | DRY MIXTURE AND PERSONAL CARE COMPOSITION AS WELL AS METHODS FOR THEIR PRODUCTION | WEIDMANN HOLDING AG (CH) | 2024-11-21 | — | — | US | disclosed |
| CN-117084953-A | Hair care or hair cleaning composition or skin care or skin cleaning composition | 魏德曼控股股份公司 | 2023-11-21 | — | — | CN | disclosed |
| EP-4265237-A1 | HAIR CARE OR HAIR CLEANSING OR SKIN CARE OR SKIN CLEANSING COMPOSITION | Weidmann Holding AG (CH) | 2023-10-25 | — | — | EP | disclosed |
| CN-116919865-A | Dry mixture | 魏德曼控股股份公司 | 2023-10-24 | — | — | CN | disclosed |
| EP-3606500-B1 | PERSONAL CARE COMPOSITION | WEIDMANN HOLDING AG (CH) | 2023-10-04 | — | — | EP | disclosed |
| EP-4239124-A2 | DRY MIXTURE | Weidmann Holding AG (CH) | 2023-09-06 | — | — | EP | disclosed |
| CN-110505868-B | Personal care compositions | 魏德曼控股股份公司 | 2023-07-28 | — | — | CN | disclosed |
| US-11696876-B2 | Hair care or hair cleansing composition or skin care or skin cleansing composition | Weidmann Holdino AG (CH) | 2023-07-11 | — | — | US | disclosed |
| US-20220160591-A1 | HAIR CARE OR HAIR CLEANSING COMPOSITION OR SKIN CARE OR SKIN CLEANSING COMPOSITION | WEIDMANN HOLDING AG (CH) | 2022-05-26 | — | — | US | disclosed |
| US-11278475-B2 | Personal care composition | WEIDMANN HOLDING AG (CH) | 2022-03-22 | — | — | US | disclosed |
| US-20210007941-A1 | PERSONAL CARE COMPOSITION | WEIDMANN HOLDING AG (CH) | 2021-01-14 | — | — | US | disclosed |
| EP-3606500-A1 | PERSONAL CARE COMPOSITION | Weidmann Holding AG (CH) | 2020-02-12 | — | — | EP | disclosed |
| WO-2018185230-A1 | PERSONAL CARE COMPOSITION | WEIDMANN HOLDING AG (CH) | 2018-10-11 | — | — | WO | disclosed |