Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of D-Glutamate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 2/20 | 0.82 |
| ▸ | GRM6 | O15303 | 2/20 | 0.82 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.82 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.82 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.82 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.82 |
| ▸ | GSR | P00390 | 1/20 | 0.82 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.82 |
| ▸ | GRM5 | P41594 | 1/20 | 0.82 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.82 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.82 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.82 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.82 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.82 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.82 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.82 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.82 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.82 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| D-Glutamate SCHEMBL28725412 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL787628 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4CYP1A2 | |
| Glutamic Acid SCHEMBL381869 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL20528822 | 1.00 | GRM8 (0.82) | GRM8GRM6GRM7GRM4CYP1A2 | |
| Glutamic Acid SCHEMBL184513 | 0.98 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 | |
| Glutamic Acid SCHEMBL2803034 | 0.98 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL15797537 | 0.98 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL184512 | 0.98 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL28509459 | 0.98 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 | |
| D-Glutamate SCHEMBL28330083 | 0.98 | GRM8 (0.86) | GRM8GRM6GRM7GRM4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117030762-A | Quasi-in-situ EBSD (electron beam diffraction) observation method for metal fatigue microstructure evolution | 北京交通大学 | 2023-11-10 | — | — | CN | claimed |
| CN-116590084-A | Rapidly biodegradable emulsified oil for hydraulic support and preparation method thereof | 福斯润滑油(中国)有限公司 | 2023-08-15 | — | — | CN | claimed |
| CN-116589379-A | Post-treatment process of m-trifluoromethyl acetophenone oxime | 河北诚信集团有限公司 | 2023-08-15 | — | — | CN | claimed |
| CN-116458503-A | Ash-staining-resistant phthalic dicarboxaldehyde disinfectant and preparation method thereof | 上海利康生物高科技有限公司 | 2023-07-21 | — | — | CN | claimed |
| CN-115926901-A | Liquid detergent composition | 广州立白企业集团有限公司 | 2023-04-07 | — | — | CN | claimed |
| CN-112028785-B | Preparation method of green chelating agent glutamic acid diacetic acid sodium salt | 河南清水源科技股份有限公司 | 2023-01-31 | — | — | CN | claimed |
| CN-115386353-A | Hypotonic oil field profile control and pressure boosting water well pressure reducing and injection increasing working fluid and preparation method thereof | 中国石油天然气集团有限公司 | 2022-11-25 | — | — | CN | claimed |
| CN-113999733-A | Granular composition and special detergent composition for dish-washing machine | 广州立白企业集团有限公司 | 2022-02-01 | — | — | CN | claimed |
| CN-112028785-A | Novel preparation method of green chelating agent glutamic acid diacetic acid sodium salt | 河南清水源科技股份有限公司 | 2020-12-04 | — | — | CN | claimed |
| CN-110771464-A | Culture solution for reducing rice cadmium accumulation in cadmium-polluted soil and rice planting method | 湖南省农业环境生态研究所 | 2020-02-11 | — | — | CN | claimed |
| CN-108690733-A | Gel detergent for kitchen use | 苏州绿叶日用品有限公司 | 2018-10-23 | — | — | CN | claimed |
| CN-106148030-B | Kitchen wet paper immersion and the preparation method and application thereof | 广州立白企业集团有限公司 | 2018-07-31 | — | — | CN | claimed |
| CN-104428404-B | Use of alkoxylated nonionic surfactants as additives in aqueous film cleaning compositions | 巴斯夫欧洲公司 | 2018-06-05 | — | — | CN | claimed |
| CN-106148030-A | Kitchen wet paper immersion and preparation method and application | 广州立白企业集团有限公司 | 2016-11-23 | — | — | CN | claimed |
| CN-104428404-A | Use of alkoxylated nonionic surfactants as additives in aqueous film cleaning compositions | BASF SE | 2015-03-18 | — | — | CN | claimed |
| US-8748364-B2 | Detergent composition containing an aminocarboxylate and a maleic copolymer | ECOLAB USA INC. (US) | 2014-06-10 | — | — | US | claimed |
| EP-2686399-A1 | TREATMENT FLUIDS CONTAINING A BIODEGRADABLE CHELATING AGENT AND METHODS FOR USE THEREOF | Halliburton Energy Services, Inc. (US) | 2014-01-22 | — | — | EP | claimed |
| WO-2012127183-A1 | TREATMENT FLUIDS CONTAINING A BIODEGRADABLE CHELATING AGENT AND METHODS FOR USE THEREOF | HALIBURTON ENERGY SERVICES, INC. (GB) | 2012-09-27 | — | — | WO | claimed |
| US-20120165237-A1 | DETERGENT COMPOSITION CONTAINING AN AMINOCARBOXYLATE AND A MALEIC COPOLYMER | ECOLAB USA INC. (US) | 2012-06-28 | — | — | US | claimed |
| US-20120067576-A1 | TREATMENT FLUIDS CONTAINING A BIODEGRADABLE CHELATING AGENT AND METHODS FOR USE THEREOF | HALLIBURTON ENERGY SERVICES, INC. (US) | 2012-03-22 | — | — | US | claimed |