Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 1/20 | 0.52 |
| ▸ | KAT7 | O95251 | 1/20 | 0.48 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 4/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | FPR3 | P25089 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20528900 | 1.00 | ACKR3 (0.52) | ACKR3KAT7KAT8BACE1USP30 | |
| SCHEMBL20528741 | 0.91 | USP30 (0.48) | ACKR3KAT7KAT8BACE1USP30 | |
| SCHEMBL20528743 | 0.91 | USP30 (0.48) | ACKR3KAT7KAT8BACE1USP30 | |
| SCHEMBL20528789 | 0.91 | ACKR3 (0.53) | ACKR3KAT7KAT8BACE1KDM4E | |
| SCHEMBL20528788 | 0.91 | ACKR3 (0.53) | ACKR3KAT7KAT8BACE1KDM4E | |
| SCHEMBL5794048 | 0.88 | ACKR3 (0.51) | ACKR3KAT7KAT8USP30SCN9A | |
| SCHEMBL5795066 | 0.83 | ACKR3 (0.46) | ACKR3KAT7KAT8BACE1SCN9A | |
| SCHEMBL5791116 | 0.81 | ACKR3 (0.55) | ACKR3KAT7KAT8BACE1USP30 | |
| SCHEMBL29242111 | 0.79 | NAMPT (0.61) | ACKR3USP30KDM4EPKMTP53 | |
| SCHEMBL5791052 | 0.78 | KMT2A (0.47) | DRD2DRD4DRD3NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11186571-B2 | Quinazolinone derivatives useful for imaging | LONDON HEALTH SCIENCES CENTRE RESEARCH INC. (CA) | 2021-11-30 | — | — | US | disclosed |
| US-20200031821-A1 | QUINAZOLINONE DERIVATIVES USEFUL FOR IMAGING | LONDON HEALTH SCIENCES CENTRE RESEARCH INC. (CA) | 2020-01-30 | — | — | US | disclosed |
| WO-2018184115-A1 | QUINAZOLINONE DERIVATIVES USEFUL FOR IMAGING | LONDON HEALTH SCIENCES CENTRE RESEARCH INC. (CA) | 2018-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200031821-A1 | QUINAZOLINONE DERIVATIVES USEFUL FOR IMAGING | TNNI3, KLK3, BRDT | ACKR3 1414/4885KAT7 366/4885KAT8 1216/4885 |
| US-11186571-B2 | Quinazolinone derivatives useful for imaging | TNNI3, KLK3, BRDT | ACKR3 1414/4885KAT7 366/4885KAT8 1216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.