Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | KAT7 | O95251 | 1/20 | 0.44 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | FPR3 | P25089 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20528743 | 1.00 | USP30 (0.48) | USP30ACKR3SCN9AKAT7KAT8 | |
| SCHEMBL20528900 | 0.91 | ACKR3 (0.52) | USP30ACKR3SCN9AKAT7KAT8 | |
| SCHEMBL20528901 | 0.91 | ACKR3 (0.52) | USP30ACKR3SCN9AKAT7KAT8 | |
| SCHEMBL5791052 | 0.88 | KMT2A (0.47) | KMT2ADRD2DRD4DRD3 | |
| SCHEMBL5794048 | 0.87 | ACKR3 (0.51) | USP30ACKR3SCN9AKAT7KAT8 | |
| SCHEMBL20528789 | 0.86 | ACKR3 (0.53) | ACKR3KAT7KAT8KMT2AFPR3 | |
| SCHEMBL20528788 | 0.86 | ACKR3 (0.53) | ACKR3KAT7KAT8KMT2AFPR3 | |
| SCHEMBL5795066 | 0.82 | ACKR3 (0.46) | ACKR3SCN9AKAT7KAT8KMT2A | |
| SCHEMBL5791116 | 0.81 | ACKR3 (0.55) | USP30ACKR3SCN9AKAT7KAT8 | |
| SCHEMBL28730423 | 0.74 | GPR119 (0.48) | BRD3KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11186571-B2 | Quinazolinone derivatives useful for imaging | LONDON HEALTH SCIENCES CENTRE RESEARCH INC. (CA) | 2021-11-30 | — | — | US | disclosed |
| US-20200031821-A1 | QUINAZOLINONE DERIVATIVES USEFUL FOR IMAGING | LONDON HEALTH SCIENCES CENTRE RESEARCH INC. (CA) | 2020-01-30 | — | — | US | disclosed |
| WO-2018184115-A1 | QUINAZOLINONE DERIVATIVES USEFUL FOR IMAGING | LONDON HEALTH SCIENCES CENTRE RESEARCH INC. (CA) | 2018-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200031821-A1 | QUINAZOLINONE DERIVATIVES USEFUL FOR IMAGING | TNNI3, KLK3, BRDT | USP30 2267/4885ACKR3 1414/4885SCN9A 863/4885 |
| US-11186571-B2 | Quinazolinone derivatives useful for imaging | TNNI3, KLK3, BRDT | USP30 2267/4885ACKR3 1414/4885SCN9A 863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.