SCHEMBL20529329

SCHEMBL20529329

NC1=NS(=O)(=O)c2ccc(Oc3ccccc3)cc21

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.53
GAA P10253 3/20 0.44
HTT P42858 2/20 0.44
MAOB P27338 4/20 0.43
MAOA P21397 4/20 0.43
GSTP1 P09211 1/20 0.40
KDM4E B2RXH2 1/20 0.40
THRB P10828 1/20 0.40
ALOX15 P16050 1/20 0.40
RECQL P46063 1/20 0.40
HSD17B10 Q99714 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
MAPT P10636 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
MITF O75030 1/20 0.40
GFER P55789 1/20 0.40
NLRP1 Q9C000 1/20 0.40
NOD2 Q9HC29 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3169495 0.75 MAOB (0.51) ALDH1A1MAOBMAOAGSTP1GRIA2
SCHEMBL299692 0.73 ALDH1A1 (0.50) ALDH1A1GAAHTTKDM4EHSD17B10
SCHEMBL3786786 0.68 MAOA (0.52) ALDH1A1GAAHTTMAOBMAOA
SCHEMBL3790623 0.65 GSTP1 (0.53) ALDH1A1GAAHTTMAOBMAOA
SCHEMBL8896688 0.64 MAOB (0.65) MAOBMAOAGSTP1TDP1MAPT
SCHEMBL3888963 0.63 LTA4H (0.71) ALDH1A1GAAMAOBMAOAGSTP1
SCHEMBL9217508 0.63 LTA4H (0.71) ALDH1A1GAAMAOBMAOAGSTP1
SCHEMBL3893288 0.63 LTA4H (0.71) ALDH1A1GAAMAOBMAOAGSTP1
SCHEMBL436010 0.63 LTA4H (0.71) ALDH1A1GAAMAOBMAOAGSTP1
SCHEMBL9216135 0.63 LTA4H (0.71) ALDH1A1GAAMAOBMAOAGSTP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3606921-A1 NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA. Inventiva (FR) 2020-02-12 EP disclosed
WO-2018185266-A1 NEW COMPOUNDS INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF MALIGNANT MESOTHELIOMA. INVENTIVA (FR) 2018-10-11 WO disclosed