SCHEMBL20529618

SCHEMBL20529618

N#Cc1ccc(NC(=O)c2ccc(F)cc2)cc1

nearest known ligand 0.70

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 1/20 0.70
PTPN1 P18031 1/20 0.67
MITF O75030 1/20 0.65
NPC1 O15118 3/20 0.62
RAB9A P51151 3/20 0.62
MEN1 O00255 6/20 0.60
KMT2A Q03164 6/20 0.60
POLB P06746 2/20 0.59
ATM Q13315 1/20 0.59
TDP1 Q9NUW8 1/20 0.59
SNCA P37840 1/20 0.58
NAMPT P43490 1/20 0.57
CYP11B1 P15538 1/20 0.56
CYP11B2 P19099 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9337665 0.91 MLYCD (0.76) MLYCDNPC1RAB9AMEN1KMT2A
SCHEMBL6263516 0.91 MLYCD (0.76) MLYCDNPC1RAB9AMEN1KMT2A
SCHEMBL10684470 0.86 PTPN1 (0.88) PTPN1MITFNPC1RAB9AMEN1
SCHEMBL31311100 0.85 MLYCD (0.68) MLYCDMITFNPC1RAB9AMEN1
SCHEMBL20764458 0.85 MLYCD (0.68) MLYCDMITFNPC1RAB9AMEN1
SCHEMBL15482261 0.85 MLYCD (0.68) MLYCDNPC1RAB9AMEN1KMT2A
SCHEMBL7272760 0.85 MLYCD (0.68) MLYCDNPC1RAB9AMEN1KMT2A
SCHEMBL6800698 0.85 MLYCD (0.68) MLYCDNPC1RAB9AMEN1KMT2A
SCHEMBL4929006 0.84 MAPT (0.69) NPC1RAB9AMEN1KMT2APOLB
SCHEMBL20941664 0.84 MAPT (0.54) MLYCDRAB9AMEN1KMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200399196-A1 Hydrogen Bond Directed Photocatalytic Hydrodefluorination and Methods of Use Thereof UNIV OKLAHOMA STATE (US) 2020-12-24 US disclosed
WO-2018187336-A1 HYDROGEN BOND DIRECTED PHOTOCATALYTIC HYDRODEFLUORINATION AND METHODS OF USE THEREOF THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY (US) 2018-10-11 WO disclosed