SCHEMBL20764458

SCHEMBL20764458

N#Cc1ccc(C(=O)Nc2ccc(C(=O)O)cc2)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 1/20 0.68
MITF O75030 1/20 0.62
MEN1 O00255 2/20 0.61
KMT2A Q03164 2/20 0.61
NPC1 O15118 1/20 0.61
RAB9A P51151 1/20 0.61
FFAR1 O14842 1/20 0.60
NAMPT P43490 2/20 0.58
F2 P00734 1/20 0.57
PLG P00747 1/20 0.57
PLAU P00749 1/20 0.57
KLKB1 P03952 1/20 0.57
PRSS1 P07477 1/20 0.57
CYP11B1 P15538 1/20 0.57
CYP11B2 P19099 1/20 0.57
ESR1 P03372 1/20 0.56
POLB P06746 1/20 0.56
MAPT P10636 1/20 0.56
PTPN11 Q06124 1/20 0.54
TAS1R3 Q7RTX0 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31311100 1.00 MLYCD (0.68) MLYCDMITFMEN1KMT2ANPC1
SCHEMBL6263516 0.93 MLYCD (0.76) MLYCDMEN1KMT2ANPC1RAB9A
SCHEMBL9337665 0.93 MLYCD (0.76) MLYCDMEN1KMT2ANPC1RAB9A
SCHEMBL1344198 0.88 F2 (0.72) MLYCDMEN1KMT2ANPC1RAB9A
SCHEMBL3190254 0.88 MEN1 (0.68) MLYCDMEN1KMT2ANPC1RAB9A
SCHEMBL9339487 0.87 P2RY14 (0.60) MLYCDMEN1KMT2ANPC1RAB9A
SCHEMBL15482261 0.86 MLYCD (0.68) MLYCDMEN1KMT2ANPC1RAB9A
SCHEMBL6800698 0.86 MLYCD (0.68) MLYCDMEN1KMT2ANPC1RAB9A
SCHEMBL7272760 0.86 MLYCD (0.68) MLYCDMEN1KMT2ANPC1RAB9A
SCHEMBL28419632 0.85 MITF (0.81) MITFMEN1KMT2ANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4731306-A1 CYSTOBACTAMID DERIVATIVES Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2026-04-29 EP disclosed
WO-2025003147-A1 CYSTOBACTAMID DERIVATIVES Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2025-01-02 WO disclosed
CN-110997627-B Cyst amide derivatives 亥姆霍兹感染研究中心有限公司 2023-10-10 CN disclosed
US-11034648-B2 Cystobactamide derivatives HELMHOLTZ-ZENTRUM FÜR (DE) 2021-06-15 US disclosed
US-11034648-B2 Cystobactamide derivatives HELMHOLTZ-ZENTRUM FÜR (DE) 2021-06-15 US disclosed
EP-3672937-A1 NOVEL CYSTOBACTAMIDE DERIVATIVES Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2020-07-01 EP disclosed
US-20200190020-A1 NOVEL CYSTOBACTAMIDE DERIVATIVES Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2020-06-18 US disclosed
US-20200190020-A1 NOVEL CYSTOBACTAMIDE DERIVATIVES Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2020-06-18 US disclosed
CN-110997627-A Novel cystobacter amide derivatives 亥姆霍兹感染研究中心有限公司 2020-04-10 CN disclosed
WO-2019038405-A1 NOVEL CYSTOBACTAMIDE DERIVATIVES Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2019-02-28 WO disclosed
WO-2019038405-A1 NOVEL CYSTOBACTAMIDE DERIVATIVES Helmholtz-Zentrum für Infektionsforschung GmbH (DE) 2019-02-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11034648-B2 Cystobactamide derivatives CTH, CBS, SLC7A11 MLYCD 301/4885MITF 4594/4885MEN1 2023/4885
US-20200190020-A1 NOVEL CYSTOBACTAMIDE DERIVATIVES CTH, CBS, SLC7A11 MLYCD 283/4885MITF 4474/4885MEN1 2097/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.