Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 4/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530354 | 0.91 | AR (0.39) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL20530364 | 0.88 | MAP4K4 (0.47) | ADORA3SLC22A12METFYNHDAC6 | |
| SCHEMBL20530305 | 0.87 | PARP1 (0.39) | ADORA2AADORA1SLC22A12METPARP1 | |
| SCHEMBL20530371 | 0.86 | MET (0.43) | ADORA2AADORA1SLC22A12METPARP1 | |
| SCHEMBL20530291 | 0.86 | PARP1 (0.38) | ADORA2AADORA1SLC22A12METPARP1 | |
| SCHEMBL20530360 | 0.86 | SLC22A12 (0.40) | ADORA2AADORA1TGFBR1SLC22A12MET | |
| SCHEMBL20530328 | 0.86 | MKNK2 (0.39) | ADORA2AADORA1SLC22A12METPARP1 | |
| SCHEMBL20530300 | 0.86 | MET (0.40) | ADORA2AADORA1ADORA3ADORA2BSLC22A12 | |
| SCHEMBL1329647 | 0.85 | MET (0.57) | TGFBR1MET | |
| SCHEMBL20530312 | 0.84 | MET (0.39) | SLC22A12METFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571878-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES | INCOZEN THERAPEUTICS PVT LTD (IN) | 2018-10-17 | — | — | EP | claimed |