Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 8/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.35 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530328 | 0.90 | MKNK2 (0.39) | SLC22A12MKNK2MKNK1PARP1PSEN1 | |
| SCHEMBL20530371 | 0.90 | MET (0.43) | SLC22A12PARP1METADORA2AADORA1 | |
| SCHEMBL20530305 | 0.89 | PARP1 (0.39) | SLC22A12MKNK2PARP1PSEN1PSEN2 | |
| SCHEMBL20530291 | 0.88 | PARP1 (0.38) | SLC22A12MKNK2PARP1METADORA2A | |
| SCHEMBL20530304 | 0.87 | ADORA2A (0.38) | SLC22A12PARP1METADORA2AADORA1 | |
| SCHEMBL20530354 | 0.87 | AR (0.39) | SLC22A12MKNK2MKNK1PARP1MET | |
| SCHEMBL20530285 | 0.86 | PDE4A (0.39) | SLC22A12PARP1METARADORA2A | |
| SCHEMBL22729912 | 0.85 | MET (0.35) | SLC22A12PSEN1PSEN2KCNH2APH1B | |
| SCHEMBL22729940 | 0.85 | MET (0.35) | SLC22A12PSEN1PSEN2KCNH2APH1B | |
| SCHEMBL22729949 | 0.85 | MET (0.35) | SLC22A12PSEN1PSEN2KCNH2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571878-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES | INCOZEN THERAPEUTICS PVT LTD (IN) | 2018-10-17 | — | — | EP | claimed |