Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 10/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ROS1 | P08922 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | FRK | P42685 | 1/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.34 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530305 | 0.94 | PARP1 (0.39) | MKNK2PARP1METSLC22A12ADORA2A | |
| SCHEMBL20530371 | 0.90 | MET (0.43) | PARP1METSLC22A12ADORA2AADORA1 | |
| SCHEMBL20530360 | 0.90 | SLC22A12 (0.40) | MKNK2MKNK1PARP1METSLC22A12 | |
| SCHEMBL20530335 | 0.89 | MET (0.47) | METSLC22A12ADORA2AADORA1MEN1 | |
| SCHEMBL20530291 | 0.88 | PARP1 (0.38) | MKNK2PARP1METSLC22A12ADORA2A | |
| SCHEMBL20530311 | 0.88 | GPR119 (0.40) | METSLC22A12ADORA2AADORA1MEN1 | |
| SCHEMBL20530304 | 0.87 | ADORA2A (0.38) | PARP1METSLC22A12ADORA2AADORA1 | |
| SCHEMBL20530307 | 0.86 | MET (0.38) | MKNK2MKNK1PARP1METMEN1 | |
| SCHEMBL20530285 | 0.86 | PDE4A (0.39) | PARP1METSLC22A12ADORA2AADORA1 | |
| SCHEMBL1329968 | 0.85 | MET (0.48) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571878-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES | INCOZEN THERAPEUTICS PVT LTD (IN) | 2018-10-17 | — | — | EP | claimed |