Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 8/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 6/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530302 | 0.89 | MET (0.51) | METADORA2AADORA1 | |
| SCHEMBL20530312 | 0.86 | MET (0.39) | METPSEN1PSEN2KCNH2APH1B | |
| SCHEMBL20530338 | 0.85 | MET (0.42) | METPSEN1PSEN2KCNH2APH1B | |
| SCHEMBL20530285 | 0.84 | PDE4A (0.39) | METADORA2AADORA1 | |
| SCHEMBL1330252 | 0.83 | MET (0.62) | MET | |
| SCHEMBL20530358 | 0.83 | MET (0.41) | METPSEN1PSEN2KCNH2APH1B | |
| SCHEMBL20530291 | 0.82 | PARP1 (0.38) | METMAP4K4ADORA2AADORA1 | |
| SCHEMBL20530371 | 0.82 | MET (0.43) | METADORA2AADORA1 | |
| SCHEMBL20530316 | 0.82 | GRM2 (0.43) | METADORA2AADORA1 | |
| SCHEMBL20530364 | 0.82 | MAP4K4 (0.47) | METMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571878-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES | INCOZEN THERAPEUTICS PVT LTD (IN) | 2018-10-17 | — | — | EP | claimed |