Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 13/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | TOP1 | P11387 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20530289 | 0.89 | MET (0.43) | METADORA2AADORA1 | |
| SCHEMBL20530286 | 0.87 | MET (0.43) | METNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL20530338 | 0.85 | MET (0.42) | METTOP1 | |
| SCHEMBL20530354 | 0.85 | AR (0.39) | METKMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL20530316 | 0.84 | GRM2 (0.43) | METCNR2MEN1NPC1KMT2A | |
| SCHEMBL20530358 | 0.83 | MET (0.41) | METNPC1RAB9AKDM4EHTT | |
| SCHEMBL20530341 | 0.82 | HDAC6 (0.43) | METKMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL20530371 | 0.82 | MET (0.43) | METADORA2AADORA1 | |
| SCHEMBL20530330 | 0.82 | MET (0.39) | METCNR2 | |
| SCHEMBL20530312 | 0.81 | MET (0.39) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571878-B1 | NOVEL 3,5-DISUBSTITUED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUED -3H-[1,2,3]TRIAZOLO[4,5-B]PYRIDINE COMPOUNDS AS MODULATORS OF PROTEIN KINASES | INCOZEN THERAPEUTICS PVT LTD (IN) | 2018-10-17 | — | — | EP | claimed |