SCHEMBL2053258

SCHEMBL2053258

Cc1nc2ccncc2cc1C(=O)N(C)[C@H](CCNC(=O)c1cccn1C)Cc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 2/20 0.56
HCRTR2 O43614 2/20 0.56
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
PADI4 Q9UM07 3/20 0.37
LMNA P02545 1/20 0.36
HRH3 Q9Y5N1 2/20 0.35
JAK2 O60674 1/20 0.35
JAK3 P52333 1/20 0.35
ALDH1A1 P00352 2/20 0.34
MEN1 O00255 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C9 P11712 1/20 0.34
CYP2C19 P33261 1/20 0.34
KMT2A Q03164 1/20 0.34
ACKR3 P25106 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2011082 1.00 HCRTR1 (0.56) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2015027 0.86 HCRTR1 (0.56) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2051297 0.84 HCRTR1 (0.62) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2014992 0.84 HCRTR1 (0.62) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2015192 0.83 HCRTR1 (0.56) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2012173 0.82 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2011717 0.82 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2014804 0.82 HCRTR1 (0.58) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2015191 0.82 HCRTR1 (0.62) HCRTR1HCRTR2NPC1RAB9APADI4
SCHEMBL2017894 0.81 HCRTR1 (0.59) HCRTR1HCRTR2NPC1RAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO disclosed
WO-2011073316-A1 4-ARYL-BUTANE-1,3-DIAMIDES NOVARTIS AG (CH) 2011-06-23 WO disclosed