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SCHEMBL20533142

SCHEMBL20533142

CC(C)(C)OC(=O)NC1CCCCc2cc(OS(=O)(=O)C(F)(F)F)ccc21

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ DRD2 P14416 1/20 0.41
▸ HTR1D P28221 1/20 0.41
▸ DRD3 P35462 1/20 0.41
▸ TAS1R3 Q7RTX0 1/20 0.41
▸ TAS1R1 Q7RTX1 1/20 0.41
▸ TAS1R2 Q8TE23 1/20 0.41
▸ BDKRB1 P46663 6/20 0.40
▸ ALDH1A1 P00352 2/20 0.39
▸ MEN1 O00255 1/20 0.38
▸ KMT2A Q03164 1/20 0.38
▸ CA12 O43570 2/20 0.37
▸ CA1 P00915 2/20 0.37
▸ CA2 P00918 2/20 0.37
▸ CA7 P43166 2/20 0.37
▸ CA9 Q16790 2/20 0.37
▸ CA14 Q9ULX7 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20533140 1.00 DRD2 (0.41) DRD2HTR1DDRD3TAS1R3TAS1R1
SCHEMBL3532957 0.97 TAS1R3 (0.44) DRD2HTR1DDRD3TAS1R3TAS1R1
SCHEMBL2629484 0.97 TAS1R3 (0.44) DRD2HTR1DDRD3TAS1R3TAS1R1
SCHEMBL5503605 0.86 TAS1R3 (0.45) TAS1R3TAS1R1TAS1R2BDKRB1ALDH1A1
SCHEMBL26052179 0.85 EPAS1 (0.34) DRD2HTR1DDRD3TAS1R3TAS1R1
SCHEMBL20533283 0.84 BTK (0.34) DRD2HTR1DDRD3BDKRB1
SCHEMBL30522345 0.84 BTK (0.34) DRD2HTR1DDRD3BDKRB1
SCHEMBL20683057 0.81 TAS1R3 (0.45) TAS1R3TAS1R1TAS1R2BDKRB1MEN1
SCHEMBL26073271 0.81 TAS1R3 (0.45) TAS1R3TAS1R1TAS1R2BDKRB1MEN1
SCHEMBL26052367 0.81 DRD2 (0.37) DRD2HTR1DDRD3TAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3609886-B1 BENZOAZEPINE ANALOGS AS INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE BIOGEN MA INC (US) 2024-02-07 — — EP disclosed
US-11858926-B2 Inhibiting agents for bruton's tyrosine kinase BIOGEN MA INC. (US) 2024-01-02 — — US disclosed
EP-4249071-A2 BENZOAZEPINE ANALOGS AS INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE Biogen MA Inc. (US) 2023-09-27 — — EP disclosed
US-20230147490-A1 INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE BIOGEN MA INC. 2023-05-11 — — US disclosed
US-11427577-B2 Inhibiting agents for Bruton's tyrosine kinase BIOGEN MA INC. (US) 2022-08-30 — — US disclosed
US-20210340135-A1 INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE BIOGEN MA INC. 2021-11-04 — — US disclosed
US-10961237-B2 Inhibiting agents for Bruton's tyrosine kinase BIOGEN MA INC. (US) 2021-03-30 — — US disclosed
US-20200239459-A1 INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE BIOGEN MA INC. 2020-07-30 — — US disclosed
EP-3609886-A1 BENZOAZEPINE ANALOGS AS INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE Biogen MA Inc. (US) 2020-02-19 — — EP disclosed
US-10227341-B2 Inhibiting agents for bruton's tyrosine kinase BIOGEN MA INC. (US) 2019-03-12 — — US disclosed
US-10189829-B2 Inhibiting agents for Bruton's tyrosine kinase BIOGEN MA INC. (US) 2019-01-29 — — US disclosed
US-20180362522-A1 INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE BIOGEN MA INC. 2018-12-20 — — US disclosed
WO-2018191577-A1 BENZOAZEPINE ANALOGS AS INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE BIOGEN MA INC. (US) 2018-10-18 — — WO disclosed
US-20180297992-A1 INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE BIOGEN MA INC. 2018-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10227341-B2 Inhibiting agents for bruton's tyrosine kinase ABL1, BTK, LYN DRD2 4832/4885HTR1D 4289/4885DRD3 4849/4885
US-10961237-B2 Inhibiting agents for Bruton's tyrosine kinase ABL1, BTK, LYN DRD2 4832/4885HTR1D 4289/4885DRD3 4849/4885
US-20210340135-A1 INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE ABL1, BTK, LYN DRD2 4832/4885HTR1D 4289/4885DRD3 4849/4885
US-20180362522-A1 INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE ABL1, BTK, LYN DRD2 4832/4885HTR1D 4289/4885DRD3 4849/4885
US-20200239459-A1 INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE ABL1, BTK, LYN DRD2 4832/4885HTR1D 4289/4885DRD3 4849/4885
US-11427577-B2 Inhibiting agents for Bruton's tyrosine kinase ABL1, BTK, LYN DRD2 4832/4885HTR1D 4289/4885DRD3 4849/4885
US-20180297992-A1 INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE ABL1, BTK, LYN DRD2 4832/4885HTR1D 4289/4885DRD3 4849/4885
US-10189829-B2 Inhibiting agents for Bruton's tyrosine kinase ABL1, BTK, LYN DRD2 4832/4885HTR1D 4289/4885DRD3 4849/4885
US-11858926-B2 Inhibiting agents for bruton's tyrosine kinase ABL1, BTK, LYN DRD2 4832/4885HTR1D 4289/4885DRD3 4849/4885
US-20230147490-A1 INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE ABL1, BTK, LYN DRD2 4832/4885HTR1D 4289/4885DRD3 4849/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.