Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.39 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3532957 | 0.89 | TAS1R3 (0.44) | TAS1R3TAS1R1TAS1R2LMNAALDH1A1 | |
| SCHEMBL2629484 | 0.89 | TAS1R3 (0.44) | TAS1R3TAS1R1TAS1R2LMNAALDH1A1 | |
| SCHEMBL20533140 | 0.86 | DRD2 (0.41) | TAS1R3TAS1R1TAS1R2ALDH1A1MEN1 | |
| SCHEMBL20533142 | 0.86 | DRD2 (0.41) | TAS1R3TAS1R1TAS1R2ALDH1A1MEN1 | |
| SCHEMBL1725707 | 0.83 | BDKRB1 (0.42) | TAS1R3TAS1R1TAS1R2LMNAALDH1A1 | |
| SCHEMBL13936478 | 0.83 | BDKRB1 (0.42) | TAS1R3TAS1R1TAS1R2LMNAALDH1A1 | |
| SCHEMBL1725709 | 0.83 | BDKRB1 (0.42) | TAS1R3TAS1R1TAS1R2LMNAALDH1A1 | |
| SCHEMBL29372292 | 0.82 | TAS1R3 (0.48) | TAS1R3TAS1R1TAS1R2LMNAALDH1A1 | |
| SCHEMBL21183420 | 0.82 | LMNA (0.51) | TAS1R3TAS1R1TAS1R2LMNAALDH1A1 | |
| SCHEMBL30444207 | 0.81 | KMT2A (0.47) | TAS1R3TAS1R1TAS1R2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817294-A1 | 1,2,3,4-TETRAHYDROPYRAZIN-2-YL ACETAMIDES AND THEIR USE AS BRADYKININ ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION RELATED DISORDERS | Amgen Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006019975-A1 | 1,2,3,4-TETRAHYDROPYRAZIN-2-YL ACETAMIDES AND THEIR USE AS BRADYKININ ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION RELATED DISORDERS | AMGEN INC. (US) | 2006-02-23 | — | — | WO | disclosed |