Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 11/20 | 0.54 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL231962 | 0.86 | HSD11B1 (0.72) | HSD11B1HSD11B2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL232860 | 0.85 | HSD11B1 (0.72) | HSD11B1HSD11B2GRM5 | |
| SCHEMBL231373 | 0.84 | HSD11B1 (0.60) | HSD11B1HSD11B2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL15899750 | 0.84 | HSD11B1 (0.55) | HSD11B1HSD11B2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3955709 | 0.83 | HSD11B1 (0.59) | HSD11B1HSD11B2 | |
| SCHEMBL6336789 | 0.81 | HSD11B1 (0.79) | HSD11B1HSD11B2ALDH1A1 | |
| SCHEMBL4215598 | 0.80 | HSD11B1 (0.57) | HSD11B1HSD11B2 | |
| SCHEMBL231374 | 0.80 | HSD11B1 (0.55) | HSD11B1HSD11B2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL4210443 | 0.79 | ALDH1A1 (0.67) | HSD11B1ALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL2229543 | 0.76 | HSD11B1 (0.51) | HSD11B1HSD11B2ALDH1A1KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011068927-A2 | 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2011-06-09 | — | — | WO | disclosed |