Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 8/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20534163 | 1.00 | ESR1 (0.61) | ESR1ESR2CYP3A4HSPD1PKM | |
| SCHEMBL9258167 | 0.91 | ESR1 (0.72) | ESR1ESR2KMT2AHSD17B3KDM4E | |
| SCHEMBL9258161 | 0.91 | ESR1 (0.72) | ESR1ESR2KMT2AHSD17B3KDM4E | |
| SCHEMBL20534185 | 0.90 | ESR1 (0.57) | ESR1ESR2CES2CES1MTNR1A | |
| SCHEMBL20534184 | 0.90 | ESR1 (0.57) | ESR1ESR2CES2CES1MTNR1A | |
| SCHEMBL4614326 | 0.89 | MTNR1A (0.53) | ESR1ESR2KMT2ACES2CES1 | |
| SCHEMBL4614904 | 0.89 | MTNR1A (0.53) | ESR1ESR2KMT2ACES2CES1 | |
| SCHEMBL6548206 | 0.86 | MAPT (0.47) | ESR1ESR2CYP3A4RAB9AKMT2A | |
| SCHEMBL9622832 | 0.86 | ESR1 (0.82) | ESR1ESR2MTNR1AMTNR1BCYP19A1 | |
| SCHEMBL3988719 | 0.86 | ESR1 (0.82) | ESR1ESR2MTNR1AMTNR1BCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10590056-B2 | ERR modulators and uses thereof | CITY OF HOPE (US) | 2020-03-17 | — | — | US | disclosed |
| US-20180297923-A1 | ERR MODULATORS AND USES THEREOF | CITY OF HOPE | 2018-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180297923-A1 | ERR MODULATORS AND USES THEREOF | ESRRA, ESRRB, ESRRG | ESR1 43/4885ESR2 7/4885CYP3A4 767/4885 |
| US-10590056-B2 | ERR modulators and uses thereof | ESRRA, ESRRB, ESRRG | ESR1 43/4885ESR2 7/4885CYP3A4 767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.