Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.48 |
| ▸ | SNCA | P37840 | 3/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | GUSB | P08236 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 2/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28253344 | 0.86 | ELANE (0.43) | APPSNCACHRM1ALDH1A1CNR1 | |
| SCHEMBL4435378 | 0.86 | CNR1 (0.54) | CHRM1ALDH1A1CNR1CNR2ELANE | |
| SCHEMBL20534349 | 0.85 | CNR1 (0.43) | CHRM1ALDH1A1CNR1CNR2ELANE | |
| SCHEMBL20534644 | 0.84 | GRIN1 (0.43) | ALDH1A1PKMP2RX7CYP11B2SRC | |
| SCHEMBL23162012 | 0.80 | P2RX7 (0.42) | APPSNCACHRM1ALDH1A1PKM | |
| SCHEMBL28252589 | 0.80 | P2RX7 (0.42) | APPSNCAALDH1A1PKMP2RX7 | |
| SCHEMBL19328149 | 0.79 | CNR1 (0.43) | CHRM1ALDH1A1CNR1CNR2ELANE | |
| SCHEMBL27625118 | 0.79 | ALDH1A1 (0.54) | APPSNCACHRM1ALDH1A1PKM | |
| SCHEMBL20140445 | 0.78 | ELANE (0.41) | CHRM1ALDH1A1CNR1CNR2ELANE | |
| SCHEMBL14853614 | 0.78 | PTGER4 (0.47) | APPSNCAALDH1A1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609883-A1 | FLUORINE-SUBSTITUTED INDAZOLE COMPOUNDS AND USES THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2020-02-19 | — | — | EP | disclosed |
| WO-2018188590-A1 | FLUORINE-SUBSTITUTED INDAZOLE COMPOUNDS AND USES THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2018-10-18 | — | — | WO | disclosed |