Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 3/20 | 0.38 |
| ▸ | SNCA | P37840 | 3/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23162012 | 0.81 | P2RX7 (0.42) | P2RX7GRIN1GRIN2BALDH1A1KDM4E | |
| SCHEMBL20534347 | 0.80 | APP (0.48) | P2RX7ALDH1A1PKMAPPSNCA | |
| SCHEMBL28956925 | 0.77 | GRIN1 (0.43) | P2RX7GRIN1GRIN2BALDH1A1KDM4E | |
| SCHEMBL20534644 | 0.77 | GRIN1 (0.43) | P2RX7GRIN1GRIN2BALDH1A1PKM | |
| SCHEMBL23161999 | 0.74 | ALDH1A1 (0.39) | P2RX7GRIN1GRIN2BALDH1A1KDM4E | |
| SCHEMBL186021 | 0.69 | GRIN1 (0.44) | GRIN1GRIN2BALDH1A1RORC | |
| SCHEMBL16252841 | 0.68 | ALDH1A1 (0.43) | ALDH1A1KDM4ERORC | |
| SCHEMBL15552018 | 0.68 | CSF1R (0.50) | P2RX7ALDH1A1KDM4EPKMCHRNB2 | |
| SCHEMBL23161955 | 0.68 | KCNK13 (0.37) | GRIN1GRIN2B | |
| SCHEMBL20140391 | 0.67 | BUB1 (0.48) | PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108727340-A | Fluorine-substituted indazole compounds and application thereof | 广东东阳光药业有限公司 | 2018-11-02 | — | — | CN | disclosed |