Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | GUCY1A1 | Q02108 | 16/20 | 0.42 |
| ▸ | GUCY1B1 | Q02153 | 16/20 | 0.42 |
| ▸ | BUB1 | O43683 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20534384 | 0.90 | ADORA3 (0.51) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL23161959 | 0.88 | ADORA3 (0.50) | ADORA3KCNH2GUCY1A1GUCY1B1BUB1 | |
| SCHEMBL30937506 | 0.88 | ADORA3 (0.50) | ADORA3KCNH2GUCY1A1GUCY1B1BUB1 | |
| SCHEMBL29382316 | 0.85 | ADORA3 (0.49) | ADORA3KCNH2GUCY1A1GUCY1B1BUB1 | |
| SCHEMBL23186729 | 0.83 | ADORA3 (0.54) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL23161945 | 0.83 | ADORA3 (0.51) | ADORA3KCNH2GUCY1A1GUCY1B1BUB1 | |
| SCHEMBL23161966 | 0.81 | ADORA3 (0.51) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL29637237 | 0.81 | ADORA3 (0.51) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL23161914 | 0.80 | ADORA3 (0.49) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A | |
| SCHEMBL29637210 | 0.80 | ADORA3 (0.49) | ADORA3KCNH2GUCY1A1GUCY1B1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609883-A1 | FLUORINE-SUBSTITUTED INDAZOLE COMPOUNDS AND USES THEREOF | Sunshine Lake Pharma Co., Ltd. (CN) | 2020-02-19 | — | — | EP | disclosed |
| WO-2018188590-A1 | FLUORINE-SUBSTITUTED INDAZOLE COMPOUNDS AND USES THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2018-10-18 | — | — | WO | disclosed |