SCHEMBL20535207

SCHEMBL20535207

COC(=O)c1ccc(CNCCCC23CC4CC(CC(C4)C2)C3)cc1

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.53
LMNA P02545 2/20 0.53
HDAC6 Q9UBN7 3/20 0.51
EPHX2 P34913 4/20 0.48
KMT2A Q03164 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
HPGD P15428 1/20 0.45
CYP4A11 Q02928 2/20 0.45
CYP4F2 P78329 1/20 0.44
HDAC11 Q96DB2 1/20 0.43
MEN1 O00255 1/20 0.42
HDAC3 O15379 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC2 Q92769 1/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
LOXL2 Q9Y4K0 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18423583 0.85 HDAC6 (0.70) ALDH1A1LMNAHDAC6EPHX2KMT2A
SCHEMBL20534925 0.84 HDAC6 (0.73) HDAC6HDAC11HDAC3HDAC1HDAC2
SCHEMBL1758674 0.79 HDAC6 (0.52) HDAC6EPHX2KMT2AHDAC11MEN1
SCHEMBL20534927 0.79 HDAC6 (0.55) ALDH1A1LMNAHDAC6EPHX2KMT2A
SCHEMBL1758919 0.79 HDAC6 (0.44) LMNAHDAC6EPHX2KMT2AHPGD
SCHEMBL18423651 0.79 ALDH1A1 (0.51) ALDH1A1LMNAHDAC6EPHX2KMT2A
SCHEMBL4928792 0.79 CYP4A11 (0.66) ALDH1A1LMNAKMT2AHPGDCYP4A11
SCHEMBL24140330 0.77 CYP4A11 (0.67) ALDH1A1LMNAHPGDCYP4A11CYP4F2
Hydrochloric Acid SCHEMBL28375976 0.77 CYP4A11 (0.64) ALDH1A1LMNAKMT2AHPGDCYP4A11
SCHEMBL3310683 0.77 LMNA (0.64) ALDH1A1LMNAKMT2AHPGDCYP4A11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3609864-A1 HDAC6 INHIBITORS AND IMAGING AGENTS The General Hospital Corporation (US) 2020-02-19 EP disclosed
WO-2018191360-A1 HDAC6 INHIBITORS AND IMAGING AGENTS THE GENERAL HOSPITAL CORPORATION (US) 2018-10-18 WO disclosed