Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.66 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 4/20 | 0.51 |
| ▸ | CA2 | P00918 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.48 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28375976 | 0.98 | CYP4A11 (0.64) | CYP4A11CYP4F2POLBLMNAHPGD | |
| SCHEMBL24140330 | 0.95 | CYP4A11 (0.67) | CYP4A11CYP4F2POLBLMNAHPGD | |
| SCHEMBL28206352 | 0.90 | CYP4A11 (0.60) | CYP4A11CYP4F2POLBLMNAHPGD | |
| SCHEMBL3310683 | 0.88 | LMNA (0.64) | CYP4A11CYP4F2LMNAHPGDLOXL2 | |
| SCHEMBL15270260 | 0.87 | S1PR1 (0.57) | CYP4A11CYP4F2LMNAHPGDLOXL2 | |
| SCHEMBL15270528 | 0.86 | CYP4A11 (0.53) | CYP4A11CYP4F2POLBLMNAHPGD | |
| SCHEMBL15270367 | 0.86 | LMNA (0.55) | CYP4A11CYP4F2POLBLMNAHPGD | |
| SCHEMBL10874890 | 0.86 | LOXL2 (0.60) | CYP4A11CYP4F2POLBLMNAHPGD | |
| Hydrochloric Acid SCHEMBL16506887 | 0.86 | S1PR1 (0.56) | CYP4A11CYP4F2LMNAHPGDLOXL2 | |
| SCHEMBL7249257 | 0.85 | LOXL2 (0.64) | CYP4A11CYP4F2POLBLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112047927-A | N-acyl-N' - (pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activity | 德西费拉制药有限责任公司 | 2020-12-08 | — | — | CN | disclosed |
| CN-105228620-B | N-acyl-N' - (pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activity | 德西费拉制药有限责任公司 | 2020-09-04 | — | — | CN | disclosed |
| EP-2968287-B1 | N-ACYL-N'-(PYRIDIN-2-YL) UREAS AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES | DECIPHERA PHARMACEUTICALS LLC (US) | 2020-06-24 | — | — | EP | disclosed |
| CN-110563700-A | N-acyl-N' - (pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activity | 德西费拉制药有限责任公司 | 2019-12-13 | — | — | CN | disclosed |
| US-10227295-B2 | Selective histone deactylase 6 inhibitors | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2019-03-12 | — | — | US | disclosed |
| US-9956192-B2 | Selective histone deactylase 6 inhibitors | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2018-05-01 | — | — | US | disclosed |
| US-20170369428-A1 | SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2017-12-28 | — | — | US | disclosed |
| US-9751832-B2 | Selective histone deactylase 6 inhibitors | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-20170035710-A1 | SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. | 2017-02-09 | — | — | US | disclosed |
| US-9409858-B2 | Selective histone deactylase 6 inhibitors | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2016-08-09 | — | — | US | disclosed |
| US-20140275080-A1 | N-Acyl-N'-(pyridin-2-yl) Ureas and Analogs Exhibiting Anti-Cancer and Anti-Proliferative Activities | DECIPHERA PHARMACEUTICALS, LLC (US) | 2014-09-18 | — | — | US | disclosed |
| WO-2013134298-A1 | RAF INHIBITOR COMPOUNDS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2013-09-12 | — | — | WO | disclosed |
| WO-2013134467-A1 | SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2013-09-12 | — | — | WO | disclosed |
| US-20080070954-A1 | Acylurea Connected And Sulfonylurea Connected Hydroxamates | S*BIO PTE LTD. (SG) | 2008-03-20 | — | — | US | disclosed |
| US-20080070954-A1 | Acylurea Connected And Sulfonylurea Connected Hydroxamates | S*BIO PTE LTD. (SG) | 2008-03-20 | — | — | US | disclosed |
| US-20080070954-A1 | Acylurea Connected And Sulfonylurea Connected Hydroxamates | S*BIO PTE LTD. (SG) | 2008-03-20 | — | — | US | disclosed |
| EP-1685094-A4 | ACYLUREA CONNECTED AND SULFONYLUREA CONNECTED HYDROXAMATES | S BIO PTE LTD (SG) | 2007-08-22 | — | — | EP | disclosed |
| EP-1685094-A1 | ACYLUREA CONNECTED AND SULFONYLUREA CONNECTED HYDROXAMATES | S*Bio Pte Ltd (SG) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005040101-A1 | ACYLUREA CONNECTED AND SULFONYLUREA CONNECTED HYDROXAMATES | S*BIO PTE LTD (SG) | 2005-05-06 | — | — | WO | disclosed |
| WO-2005040101-A1 | ACYLUREA CONNECTED AND SULFONYLUREA CONNECTED HYDROXAMATES | S*BIO PTE LTD (SG) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275080-A1 | N-Acyl-N'-(pyridin-2-yl) Ureas and Analogs Exhibiting Anti-Cancer and Anti-Proliferative Activities | KIT, CSF1R, CSF3R | CYP4A11 4712/4885CYP4F2 3735/4885POLB 2053/4885 |
| US-20080070954-A1 | Acylurea Connected And Sulfonylurea Connected Hydroxamates | HDAC1, HDAC3, HDAC4 | CYP4A11 4616/4885CYP4F2 4065/4885POLB 2092/4885 |
| US-20170035710-A1 | SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS | HDAC1, HDAC5, HDAC11 | CYP4A11 4413/4885CYP4F2 4146/4885POLB 408/4885 |
| US-20170369428-A1 | SELECTIVE HISTONE DEACTYLASE 6 INHIBITORS | HDAC1, HDAC5, HDAC11 | CYP4A11 4371/4885CYP4F2 4046/4885POLB 414/4885 |
| US-10227295-B2 | Selective histone deactylase 6 inhibitors | HDAC1, HDAC5, HDAC11 | CYP4A11 4371/4885CYP4F2 4046/4885POLB 414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.