Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | IKBKB | O14920 | 2/20 | 0.47 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20534966 | 0.89 | KDM4E (0.72) | KDM4EALDH1A1HPGDHSD17B10IKBKB | |
| SCHEMBL13699672 | 0.86 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10IKBKB | |
| SCHEMBL4257410 | 0.84 | KDM4E (0.77) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL13335687 | 0.83 | NPC1 (0.46) | KDM4EALDH1A1HPGDHSD17B10SLC9A1 | |
| SCHEMBL20535434 | 0.81 | KDM4E (0.51) | KDM4EALDH1A1HPGDHSD17B10IKBKB | |
| SCHEMBL20535012 | 0.81 | PGR (0.45) | KDM4EALDH1A1HPGDHSD17B10IKBKB | |
| SCHEMBL20534818 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10CA12 | |
| SCHEMBL20535441 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10CA12 | |
| SCHEMBL20535054 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1HPGDHSD17B10CA12 | |
| SCHEMBL20535045 | 0.80 | KDM4E (0.51) | KDM4EALDH1A1HPGDHSD17B10IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018189683-A1 | BENZOFURAN DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | claimed |
| WO-2018189683-A1 | BENZOFURAN DERIVATIVES FOR USE AS AMPK ACTIVATORS | UNIVERSITA' DI PISA (IT) | 2018-10-18 | — | — | WO | disclosed |