Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.41 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.41 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.41 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20536399 | 1.00 | MAPT (0.41) | MAPTLMNAMEN1KMT2APOLB | |
| SCHEMBL22620595 | 0.81 | MAPT (0.44) | MAPTLMNAMEN1KMT2APOLB | |
| SCHEMBL25288403 | 0.80 | MAPT (0.47) | MAPTLMNAMEN1KMT2APOLB | |
| SCHEMBL31295218 | 0.79 | NR1H4 (0.42) | MAPTLMNAMEN1KMT2APOLB | |
| SCHEMBL20535751 | 0.79 | L3MBTL1 (0.38) | MAPTLMNAMEN1KMT2APOLB | |
| SCHEMBL20535753 | 0.79 | L3MBTL1 (0.38) | MAPTLMNAMEN1KMT2APOLB | |
| SCHEMBL28455695 | 0.79 | MAPT (0.42) | MAPTLMNAMEN1KMT2APOLB | |
| SCHEMBL29813127 | 0.78 | MAPT (0.38) | MAPTLMNAMEN1KMT2APOLB | |
| SCHEMBL23170014 | 0.78 | MAPT (0.38) | MAPTLMNAMEN1KMT2APOLB | |
| SCHEMBL23709914 | 0.78 | LMNA (0.47) | MAPTLMNAMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018191146-A1 | HETEROARYL RHEB INHIBITORS AND USES THEREOF | NAVITOR PHARMACEUTICALS, INC. (US) | 2018-10-18 | — | — | WO | disclosed |