Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | MB | P02144 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | RARG | P13631 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30230771 | 0.82 | POLB (0.63) | POLBPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL15094312 | 0.82 | POLB (0.63) | POLBPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8540010 | 0.81 | POLB (0.47) | POLBPKMSMN1; SMN2MEN1KMT2A | |
| Benzene SCHEMBL9058508 | 0.80 | POLB (0.46) | POLBPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL28837437 | 0.79 | POLB (0.50) | POLBPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL31198180 | 0.77 | POLB (0.58) | POLBPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8205051 | 0.74 | GABRA1 (0.53) | POLBPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9773576 | 0.73 | POLB (0.50) | POLBPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL28627643 | 0.73 | EGFR (0.57) | POLBPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL5837263 | 0.72 | POLB (0.54) | POLBPKMSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11571416-B2 | Amodiaquine analogs and methods of uses thereof | KAGOSHIMA UNIVERSITY (JP) | 2023-02-07 | — | — | US | disclosed |
| US-20200113891-A1 | NOVEL AMODIAQUINE ANALOGS AND METHODS OF USES THEREOF | KAGOSHIMA UNIVERSITY (JP) | 2020-04-16 | — | — | US | disclosed |
| WO-2018191642-A1 | NOVEL AMODIAQUINE ANALOGS AND METHODS OF USES THEREOF | TEXAS BIOMEDICAL RESEARCH INSTITUTE (US) | 2018-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11571416-B2 | Amodiaquine analogs and methods of uses thereof | HAVCR2, SARS1, XPA | POLB 1582/4885PKM 1954/4885SMN1; SMN2 2637/4885 |
| US-20200113891-A1 | NOVEL AMODIAQUINE ANALOGS AND METHODS OF USES THEREOF | HAVCR2, SARS1, XPA | POLB 1508/4885PKM 2238/4885SMN1; SMN2 3209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.