Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.51 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15094312 | 0.89 | POLB (0.63) | POLBALDH1A1MEN1KMT2ATHRB | |
| SCHEMBL30230771 | 0.89 | POLB (0.63) | POLBALDH1A1MEN1KMT2ATHRB | |
| SCHEMBL10445580 | 0.85 | POLB (0.48) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL29939067 | 0.84 | POLB (0.53) | POLBALDH1A1MEN1KMT2ATHRB | |
| SCHEMBL9582949 | 0.84 | POLB (0.53) | POLBALDH1A1MEN1KMT2ATHRB | |
| SCHEMBL9603796 | 0.84 | POLB (0.47) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL2855498 | 0.84 | POLB (0.63) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL15279552 | 0.81 | POLB (0.49) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL24403490 | 0.80 | EPHX2 (0.46) | POLBALDH1A1THRBL3MBTL1SMN1; SMN2 | |
| SCHEMBL6402141 | 0.80 | POLB (0.58) | POLBALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132431-B2 | Anti-malarial compounds | THE UNIVERSITY OF LIVERPOOL (GB) | 2006-11-07 | — | — | US | disclosed |
| US-20040152729-A1 | Anti-malarial compounds | THE LIVERPOOL SCHOOL OF TROPICAL MEDICINE (GB) | 2004-08-05 | — | — | US | disclosed |
| EP-1368321-A1 | ANTI-MALARIAL COMPOUNDS | THE UNIVERSITY OF LIVERPOOL (GB) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002072554-A1 | ANTI-MALARIAL COMPOUNDS | THE UNIVERSITY OF LIVERPOOL (GB) | 2002-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152729-A1 | Anti-malarial compounds | HMBS, MEP1A, QDPR | POLB 990/4885ALDH1A1 4003/4885MEN1 3050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.