SCHEMBL20537009

SCHEMBL20537009

C=CCOc1ccc2c(O)cccc2c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.46
PLAU P00749 1/20 0.45
CA12 O43570 5/20 0.44
CA1 P00915 5/20 0.44
CA9 Q16790 5/20 0.44
MTNR1A P48039 2/20 0.44
MAPT P10636 3/20 0.44
MEN1 O00255 1/20 0.44
LMNA P02545 1/20 0.44
KMT2A Q03164 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
SLC5A1 P13866 1/20 0.43
SLC5A2 P31639 1/20 0.43
ESR1 P03372 2/20 0.42
ESR2 Q92731 2/20 0.42
HSD17B1 P14061 1/20 0.42
HSD17B2 P37059 1/20 0.42
ALDH1A1 P00352 1/20 0.42
GAA P10253 1/20 0.42
ALDH2 P05091 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20537232 0.88 MTNR1A (0.53) HPGDCA12CA1CA9MTNR1A
SCHEMBL11580959 0.83 NQO2 (0.50) HPGDCA12CA1CA9MAPT
SCHEMBL3822410 0.83 CYP3A4 (0.49) HPGDCA12CA1CA9MTNR1A
SCHEMBL7650010 0.81 CA12 (0.57) HPGDCA12CA1CA9MTNR1A
SCHEMBL13888301 0.81 CA12 (0.44) HPGDCA12CA1CA9MTNR1A
SCHEMBL10591673 0.79 CA12 (0.46) HPGDCA12CA1CA9MTNR1A
SCHEMBL14686064 0.79 MAPT (0.51) PLAUMTNR1AMAPTMEN1KMT2A
SCHEMBL470906 0.78 CA12 (0.57) CA12CA1CA9MTNR1AMAPT
SCHEMBL30541768 0.78 CA12 (0.57) CA12CA1CA9MTNR1AMAPT
SCHEMBL26208605 0.77 MTNR1A (0.42) HPGDCA12CA1CA9MTNR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108368069-B Oxazine compound, composition and cured product DIC株式会社 2022-10-14 CN disclosed
CN-108473642-B Oxazine compound, composition and cured product DIC株式会社 2021-05-07 CN disclosed
US-10913725-B2 Oxazine compound, composition and cured product DIC CORPORATION (JP) 2021-02-09 US disclosed
US-10399312-B2 Oxazine compound, composition and cured product DIC CORPORATION (JP) 2019-09-03 US disclosed
US-20180362479-A1 OXAZINE COMPOUND, COMPOSITION AND CURED PRODUCT DIC CORPORATION (JP) 2018-12-20 US disclosed
US-20180333941-A1 OXAZINE COMPOUND, COMPOSITION AND CURED PRODUCT DIC CORPORATION (JP) 2018-11-22 US disclosed
EP-3401311-A1 OXAZINE COMPOUND, COMPOSITION AND CURED PRODUCT DIC Corporation (JP) 2018-11-14 EP disclosed
EP-3392281-A1 OXAZINE COMPOUND, COMPOSITION AND CURED PRODUCT DIC Corporation (JP) 2018-10-24 EP disclosed
CN-108368069-A Oxazine compound, composition and cured product DIC株式会社 2018-08-03 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180333941-A1 OXAZINE COMPOUND, COMPOSITION AND CURED PRODUCT KDM5A, PSMB5, CUL5 HPGD 1322/4885PLAU 4240/4885CA12 782/4885
US-10913725-B2 Oxazine compound, composition and cured product PSMB5, KDM5A, CUL5 HPGD 1165/4885PLAU 4138/4885CA12 974/4885
US-20180362479-A1 OXAZINE COMPOUND, COMPOSITION AND CURED PRODUCT PSMB5, KDM5A, CUL5 HPGD 1165/4885PLAU 4138/4885CA12 974/4885
US-10399312-B2 Oxazine compound, composition and cured product KDM5A, PSMB5, CUL5 HPGD 1322/4885PLAU 4240/4885CA12 782/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.