Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.75 |
| ▸ | HMGCR | P04035 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 4/20 | 0.38 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.38 |
| ▸ | CPT2 | P23786 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28100869 | 1.00 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL2284616 | 1.00 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28591636 | 1.00 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1470535 | 0.98 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL3323217 | 0.98 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL3825579 | 0.97 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL5464340 | 0.95 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL6571073 | 0.95 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL7047617 | 0.95 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL347802 | 0.95 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12036513-B2 | Desalination performance restoration agent for cellulose acetate membrane and desalination performance restoration method for cellulose acetate membrane | MITSUBISHI HEAVY INDUSTRIES, LTD. (JP) | 2024-07-16 | — | — | US | disclosed |
| US-12005399-B2 | — | — | 2024-06-11 | — | — | US | disclosed |
| CN-116641245-B | Digital printing technology for chinlon | 绍兴乾雍纺织有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-117110128-B | Quantitative test method for gamma' -phase mass fraction in nickel-based powder superalloy | 中国航发北京航空材料研究院 | 2024-01-30 | — | — | CN | disclosed |
| CN-117110128-B | Quantitative test method for gamma' -phase mass fraction in nickel-based powder superalloy | 中国航发北京航空材料研究院 | 2024-01-30 | — | — | CN | disclosed |
| CN-117110128-A | Quantitative test method for gamma' -phase mass fraction in nickel-based powder superalloy | 中国航发北京航空材料研究院 | 2023-11-24 | — | — | CN | disclosed |
| CN-117110128-A | Quantitative test method for gamma' -phase mass fraction in nickel-based powder superalloy | 中国航发北京航空材料研究院 | 2023-11-24 | — | — | CN | disclosed |
| CN-116641245-A | Digital printing technology for chinlon | 绍兴乾雍纺织有限公司 | 2023-08-25 | — | — | CN | disclosed |
| CN-106661418-B | Adhesive agent | 克瑙夫绝缘私人有限公司 | 2021-07-09 | — | — | CN | disclosed |
| EP-3390388-A1 | LANTHANIDE COMPLEXES FOR CRYSTALLISING BIOLOGICAL MACROMOLECULES AND DETERMINING THE CRYSTALLOGRAPHIC STRUCTURE THEREOF | Ecole Normale Superieure De Lyon (FR) | 2018-10-24 | — | — | EP | disclosed |
| CN-106661418-A | Adhesive agent | 克瑙夫绝缘私人有限公司 | 2017-05-10 | — | — | CN | disclosed |
| CN-103443196-A | Aqueous fluoropolymer dispersion | DAIKIN IND LTD | 2013-12-11 | — | — | CN | disclosed |