Citric Acid

Citric Acid

SCHEMBL6571073

O=C(O)CC(O)(CC(=O)O)C(=O)O.O=S(=O)(O)O.[MgH2]

nearest known ligand 0.75

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.37
ALDH1A1 P00352 3/20 0.75
HMGCR P04035 1/20 0.40
CHRM1 P11229 1/20 0.40
TBXA2R P21731 1/20 0.40
ADRA1A P35348 1/20 0.40
TSHR P16473 2/20 0.39
CYP2D6 P10635 2/20 0.39
KDM4E B2RXH2 2/20 0.39
LMNA P02545 2/20 0.39
CYP2C19 P33261 1/20 0.39
HIF1A Q16665 1/20 0.39
MAPT P10636 1/20 0.39
ALOX15 P16050 1/20 0.39
ACLY P53396 4/20 0.38
SLC13A5 Q86YT5 4/20 0.38
CPT2 P23786 1/20 0.37
CYP1A2 P05177 1/20 0.37
KMT2A Q03164 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL28115925 0.98 ALDH1A1 (0.71) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL5046946 0.98 ALDH1A1 (0.71) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL3825579 0.97 ALDH1A1 (0.79) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL7563521 0.95 ALDH1A1 (0.68) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL5464340 0.95 ALDH1A1 (0.75) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL7047617 0.95 ALDH1A1 (0.75) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL347802 0.95 ALDH1A1 (0.75) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL20537178 0.95 ALDH1A1 (0.75) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL28591636 0.95 ALDH1A1 (0.75) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL19926506 0.95 ALDH1A1 (0.75) ALDH1A1HMGCRCHRM1TBXA2RADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109310774-A Containing can sulfate and magnesium citrate liquid preparation 费林股份公司 2019-02-05 CN disclosed
EP-1406993-A1 METHOD FOR IMPROVING EFFERVESCENCY OF A DETERGENT PRODUCT THE PROCTER & GAMBLE COMPANY (US) 2004-04-14 EP disclosed
CN-1427882-A Liquid detergent compositions PROCTER & GAMBLE (US) 2003-07-02 CN disclosed
CN-1423690-A Detergent compositions PROCTER & GAMBLE (US) 2003-06-11 CN disclosed
CN-1415006-A Washing methods utilizing effervescent product added prior to agitation PROCTER & GAMBLE (US) 2003-04-30 CN disclosed
CN-1415008-A Detergent compositions and methods for cleaning PROCTER & GAMBLE (US) 2003-04-30 CN disclosed
CN-1415005-A Detergent composition PROCTER & GAMBLE (US) 2003-04-30 CN disclosed
CN-1415007-A Detergent compositions PROCTER & GAMBLE (US) 2003-04-30 CN disclosed
CN-1413248-A Laundry and cleaning and/or fabric care compositions PROCTER & GAMBLE (US) 2003-04-23 CN disclosed
CN-1399673-A Detergent particles and methods for making them PROCTER & GAMBLE (US) 2003-02-26 CN disclosed
WO-2001011005-A1 GRANULAR DETERGENT COMPOSITIONS HAVING SURFACTANT PARTICLE WITH REDUCED ELECTROLYTE CONCENTRATIONS THE PROCTER & GAMBLE COMPANY (US) 2001-02-15 WO disclosed
CN-1278862-A Cleaning compositions PROCTER & GAMBLE (US) 2001-01-03 CN disclosed
CN-1278861-A Cleaning compositions PROCTER & GAMBLE (US) 2001-01-03 CN disclosed
WO-2000078908-A1 DETERGENT PARTICLES AND PROCESSES FOR MAKING THEM THE PROCTER & GAMBLE COMPANY (US) 2000-12-28 WO disclosed
WO-2000078914-A1 DETERGENT PARTICLES AND METHODS FOR MAKING THEM THE PROCTER & GAMBLE COMPANY (US) 2000-12-28 WO disclosed
CN-1278297-A Detergent compositions PROCTER & GAMBLE (US) 2000-12-27 CN disclosed
CN-1278294-A Bleaching composition PROCTER & GAMBLE (US) 2000-12-27 CN disclosed
WO-2000022091-A1 DETERGENT COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 2000-04-20 WO disclosed
WO-2000018856-A1 DETERGENT GRANULES THE PROCTER & GAMBLE COMPANY (US) 2000-04-06 WO disclosed
CN-1238801-A Detergent composition or component PROCTER & GAMBLE (US) 1999-12-15 CN disclosed