Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20536415 | 0.91 | L3MBTL1 (0.53) | L3MBTL1ALDH1A1NPC1KMT2AMAPT | |
| SCHEMBL20536802 | 0.90 | KDM4E (0.53) | KDM4EL3MBTL1ALDH1A1KMT2AMAPT | |
| SCHEMBL14871708 | 0.85 | KDM4E (0.62) | KDM4EALDH1A1NPC1KMT2ASMN1; SMN2 | |
| SCHEMBL20537077 | 0.82 | USP30 (0.49) | KDM4EL3MBTL1ALDH1A1NPC1KMT2A | |
| SCHEMBL1980829 | 0.81 | HDAC6 (0.53) | KDM4EALDH1A1NPC1KMT2AMAPT | |
| SCHEMBL20537300 | 0.80 | SMN1; SMN2 (0.53) | L3MBTL1ALDH1A1KMT2AMAPTNAMPT | |
| SCHEMBL1787470 | 0.80 | ALDH1A1 (0.56) | KDM4EL3MBTL1ALDH1A1NPC1KMT2A | |
| SCHEMBL1789738 | 0.78 | SMN1; SMN2 (0.55) | KDM4ENPC1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL1028559 | 0.77 | KMT2A (0.59) | NPC1KMT2AMAPTNAMPTTDP1 | |
| SCHEMBL1790748 | 0.77 | KDM4E (0.54) | KDM4EALDH1A1NPC1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438055-B1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | JAPAN TOBACCO INC (JP) | 2018-10-24 | — | — | EP | claimed |