Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14809370 | 0.87 | CSNK1D (0.36) | KDM4EALDH1A1EGLN1KMT2AMEN1 | |
| SCHEMBL2566342 | 0.81 | ALDH1A1 (0.48) | KDM4EALDH1A1KMT2AMEN1GAA | |
| SCHEMBL20538492 | 0.81 | EGLN1 (0.55) | ALDH1A1EGLN1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL20538371 | 0.79 | POLB (0.43) | KDM4EALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL20538520 | 0.76 | KMT2A (0.38) | KDM4EALDH1A1EGLN1KMT2AMEN1 | |
| SCHEMBL14812344 | 0.75 | EGLN1 (0.42) | KDM4EALDH1A1EGLN1KMT2ALMNA | |
| SCHEMBL14812339 | 0.75 | EGLN1 (0.42) | KDM4EALDH1A1EGLN1KMT2ALMNA | |
| SCHEMBL14821260 | 0.75 | EGLN1 (0.42) | KDM4EALDH1A1EGLN1KMT2ALMNA | |
| SCHEMBL14809279 | 0.74 | WNT3A (0.44) | — | |
| SCHEMBL14809241 | 0.71 | EGLN1 (0.50) | ALDH1A1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758059-B1 | SUBSTITUTED PYRIMIDINES | MERCK SHARP & DOHME (US) | 2018-10-24 | — | — | EP | claimed |