Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2576826 | 0.91 | KMT2A (0.45) | KMT2AMEN1GAATMIGD3KDM4E | |
| SCHEMBL20538532 | 0.88 | POLB (0.36) | KMT2AMEN1KDM4EALDH1A1EGLN1 | |
| SCHEMBL14808802 | 0.87 | CSNK1D (0.36) | KMT2AMEN1GAATMIGD3KDM4E | |
| SCHEMBL20538664 | 0.86 | FFAR2 (0.38) | KMT2AMEN1EGLN1LMNA | |
| SCHEMBL2566721 | 0.81 | POLB (0.45) | KDM4EEGLN1LMNAMAPK1POLB | |
| SCHEMBL14808763 | 0.80 | EGLN1 (0.54) | EGLN1LMNAMAPK1 | |
| SCHEMBL2561322 | 0.79 | LMNA (0.45) | EGLN1LMNAMAPK1 | |
| SCHEMBL2568960 | 0.79 | POLB (0.49) | GAAALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL20538380 | 0.78 | EGLN1 (0.36) | KMT2AMEN1KDM4EALDH1A1EGLN1 | |
| SCHEMBL2565273 | 0.77 | MAPK1 (0.55) | GAAEGLN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2758059-B1 | SUBSTITUTED PYRIMIDINES | MERCK SHARP & DOHME (US) | 2018-10-24 | — | — | EP | claimed |