Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 6/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 4/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20539857 | 0.81 | PDCD1 (0.38) | PDCD1CD274MAPK1TP53RAB9A | |
| SCHEMBL28360304 | 0.80 | CYP2D6 (0.36) | ADRB2ADRB1PDCD1CD274TDP1 | |
| SCHEMBL29997360 | 0.74 | PDCD1 (0.50) | ADRB2PDCD1CD274HTR7MAPK1 | |
| SCHEMBL4551683 | 0.74 | KDM4E (0.54) | ADRB2ADRB1TDP1LMNAKDM4E | |
| SCHEMBL13984211 | 0.73 | ALOX15 (0.53) | RAB9ATDP1L3MBTL1LMNAKDM4E | |
| SCHEMBL14364260 | 0.72 | MCHR1 (0.45) | ADRB2ADRB1PDCD1CD274HTR7 | |
| SCHEMBL20540087 | 0.71 | S1PR1 (0.40) | PDCD1CD274MAPK1TP53RAB9A | |
| SCHEMBL20539635 | 0.71 | PTPN1 (0.34) | PDCD1CD274MAPK1TP53RAB9A | |
| SCHEMBL32930869 | 0.71 | SMN1; SMN2 (0.47) | MAPK1TP53RAB9ALMNAKDM4E | |
| SCHEMBL1919969 | 0.71 | LMNA (0.54) | TDP1L3MBTL1LMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180305315-A1 | PD-1/PD-L1 INHIBITORS | GILEAD SCIENCES, INC. | 2018-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180305315-A1 | PD-1/PD-L1 INHIBITORS | CD274, PDCD1, PDCD1LG2 | ADRB2 3161/4885ADRB1 2106/4885PDCD1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.