Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 10/20 | 0.48 |
| ▸ | MAOA | P21397 | 6/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.41 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 4/20 | 0.39 |
| ▸ | CA9 | Q16790 | 4/20 | 0.39 |
| ▸ | CA4 | P22748 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | GMPS | P49915 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13338101 | 0.85 | MAOB (0.59) | MAOBMAOAGSTP1CA12CA9 | |
| SCHEMBL10576255 | 0.80 | TP53 (0.53) | MAOBMAOAGSTP1CA12CA9 | |
| SCHEMBL791878 | 0.80 | MAOB (0.54) | MAOBMAOATSHR | |
| SCHEMBL13165218 | 0.79 | SOD1 (0.49) | MAOBMAOAGSTP1CA12CA9 | |
| SCHEMBL260934 | 0.79 | KIF11 (0.47) | MAOBEGLN1EGLN3CA9CA1 | |
| SCHEMBL13498453 | 0.79 | MAOB (0.44) | MAOBMAOAGSTP1CA12CA9 | |
| SCHEMBL22924645 | 0.78 | TP53 (0.55) | CYP1A2KDM4EALDH1A1GAATSHR | |
| SCHEMBL2846222 | 0.77 | MAOB (0.51) | MAOBMAOAGSTP1GMPSCYP1A1 | |
| SCHEMBL4815490 | 0.77 | MAOB (0.52) | MAOBMAOAGSTP1KDM4EALDH1A1 | |
| Ethylene SCHEMBL27903208 | 0.75 | TP53 (0.52) | CYP1A2KDM4EALDH1A1GAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10889546-B2 | Alkynyl pyridine prolyl hydroxylase inhibitor, and preparation method and medical use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2021-01-12 | — | — | US | disclosed |
| US-20200407319-A1 | ALKYNYL PYRIDINE PROLYL HYDROXYLASE INHIBITOR, AND PREPARATION METHOD AND MEDICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. | 2020-12-31 | — | — | US | disclosed |
| EP-3360862-B1 | ALKYNYL PYRIDINE PROLYL HYDROXYLASE INHIBITOR, AND PREPARATION METHOD AND MEDICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2020-04-22 | — | — | EP | disclosed |
| US-20180305317-A1 | ALKYNYL PYRIDINE PROLYL HYDROXYLASE INHIBITOR, AND PREPARATION METHOD AND MEDICAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2018-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180305317-A1 | ALKYNYL PYRIDINE PROLYL HYDROXYLASE INHIBITOR, AND PREPARATION METHOD AND MEDICAL USE THEREOF | EGLN3, EGLN2, EPOR | MAOB 303/4885MAOA 464/4885EGLN1 10/4885 |
| US-10889546-B2 | Alkynyl pyridine prolyl hydroxylase inhibitor, and preparation method and medical use thereof | EGLN3, EGLN2, EPOR | MAOB 303/4885MAOA 464/4885EGLN1 10/4885 |
| US-20200407319-A1 | ALKYNYL PYRIDINE PROLYL HYDROXYLASE INHIBITOR, AND PREPARATION METHOD AND MEDICAL USE THEREOF | EGLN3, EGLN2, EPOR | MAOB 303/4885MAOA 464/4885EGLN1 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.