Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.51 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL20541546 | 1.00 | TDP1 (0.58) | TDP1L3MBTL1ACHECHRM2HTR1A | |
| Bromide SCHEMBL20541913 | 1.00 | TDP1 (0.58) | TDP1L3MBTL1ACHECHRM2HTR1A | |
| Bromide SCHEMBL20541389 | 1.00 | TDP1 (0.58) | TDP1L3MBTL1ACHECHRM2HTR1A | |
| Bromide SCHEMBL1579652 | 1.00 | TDP1 (0.58) | TDP1L3MBTL1ACHECHRM2HTR1A | |
| Bromide SCHEMBL1325100 | 0.98 | TDP1 (0.55) | TDP1L3MBTL1ACHEMAPTRAB9A | |
| Bromide SCHEMBL517469 | 0.94 | TDP1 (0.53) | TDP1L3MBTL1CHRM2MAPTRAB9A | |
| Bromide SCHEMBL29425571 | 0.94 | TDP1 (0.53) | TDP1L3MBTL1CHRM2MAPTRAB9A | |
| SCHEMBL14764997 | 0.89 | TDP1 (0.50) | TDP1L3MBTL1ACHECHRM2 | |
| Bromide SCHEMBL6664857 | 0.87 | CASP3 (0.51) | TDP1L3MBTL1CHRM2MAPTRAB9A | |
| Bromide SCHEMBL20541573 | 0.85 | RAB9A (0.56) | CHRM2HTR1ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018193126-A1 | AZITHROMYCIN DERIVATIVES CONTAINING A PHOSPHONIUM ION AS ANTIBACTERIAL AGENTS | NOVINTUM BIOTECHNOLOGY GMBH (CH) | 2018-10-25 | — | — | WO | disclosed |
| WO-2018193116-A1 | AZITHROMYCIN DERIVATIVES CONTAINING A PHOSPHONIUM ION AS ANTICANCER AGENTS | NOVINTUM BIOTECHNOLOGY GMBH (CH) | 2018-10-25 | — | — | WO | disclosed |