Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL29425571 | 1.00 | TDP1 (0.53) | TDP1L3MBTL1MAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL1325100 | 0.95 | TDP1 (0.55) | TDP1L3MBTL1MAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL20541913 | 0.94 | TDP1 (0.58) | TDP1L3MBTL1MAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL20541546 | 0.94 | TDP1 (0.58) | TDP1L3MBTL1MAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL20541445 | 0.94 | TDP1 (0.58) | TDP1L3MBTL1MAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL1579652 | 0.94 | TDP1 (0.58) | TDP1L3MBTL1MAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL20541389 | 0.94 | TDP1 (0.58) | TDP1L3MBTL1MAPTRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL6664857 | 0.90 | CASP3 (0.51) | TDP1L3MBTL1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL14764997 | 0.83 | TDP1 (0.50) | TDP1L3MBTL1CYP1A2CYP2C19CHRM2 | |
| Bromide SCHEMBL20541573 | 0.79 | RAB9A (0.56) | RAB9ACYP1A2CYP2D6CYP2C19CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114181039-A | Synthetic method of 4, 4-diphenyl-3-buten-1-ol | 凯美克(上海)医药科技有限公司 | 2022-03-15 | — | — | CN | claimed |
| CN-114181039-A | Synthetic method of 4, 4-diphenyl-3-buten-1-ol | 凯美克(上海)医药科技有限公司 | 2022-03-15 | — | — | CN | disclosed |
| CN-114181039-A | Synthetic method of 4, 4-diphenyl-3-buten-1-ol | 凯美克(上海)医药科技有限公司 | 2022-03-15 | — | — | CN | disclosed |
| EP-3265458-B1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2018-12-19 | — | — | EP | disclosed |
| EP-3265458-A1 | BENZAZEPINE DICARBOXAMIDE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2018-01-10 | — | — | EP | disclosed |
| US-9822065-B1 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-11-21 | — | — | US | disclosed |
| EP-3144303-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | Array Biopharma, Inc. (US) | 2017-03-22 | — | — | EP | disclosed |
| US-9597333-B2 | Benzazepine dicarboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-03-21 | — | — | US | disclosed |
| US-9556139-B2 | 6-substituted phenoxychroman carboxylic acid derivatives | ARRAY BIOPHARMA INC. (US) | 2017-01-31 | — | — | US | disclosed |
| US-20170014423-A1 | Benzazepine Dicarboxamide Compounds | HOFFMANN-LA ROCHE INC. (US) | 2017-01-19 | — | — | US | disclosed |
| US-20140005418-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC. (US) | 2014-01-02 | — | — | US | disclosed |
| US-8569522-B2 | 6-substituted phenoxychroman carboxylic acid derivatives | ARRAY BIOPHARMA INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20120028971-A1 | OXO-HETEROCYCLICALLY SUBSTITUTED ALKYL CARBOXYLIC ACIDS AND USE THEREOF | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-02-02 | — | — | US | disclosed |
| EP-2406215-A1 | OXO-HETEROCYCLICALLY SUBSTITUTED ALKYL CARBOXYLIC ACIDS AND USE THEREOF | Bayer Pharma Aktiengesellschaft (DE) | 2012-01-18 | — | — | EP | disclosed |
| US-20110105463-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC. (US) | 2011-05-05 | — | — | US | disclosed |
| WO-2010102717-A1 | OXO-HETEROCYCLICALLY SUBSTITUTED ALKYL CARBOXYLIC ACIDS AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-09-16 | — | — | WO | disclosed |
| US-7084154-B2 | 2-(aminomethyl) arylamide analgesics | PHARMACOPEIA DRUG DISCLOVERY, INC. (US) | 2006-08-01 | — | — | US | disclosed |
| US-20040167119-A1 | 2-(aminomethyl) arylamide analgesics | PHARMACOPEIA, INC (US) | 2004-08-26 | — | — | US | disclosed |
| WO-2004071445-A2 | 2-(AMINOMETHYL)ARYLAMIDE ANALGESICS | PHARMACOPEIA DRUG DISCOVERY, INC. (US) | 2004-08-26 | — | — | WO | disclosed |
| US-4134918-A | ENZYME INHIBITORS, ANTIBODY INHIBITORS | MERRELL TORAUDE ET COMPAGNIE (FR) | 1979-01-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170014423-A1 | Benzazepine Dicarboxamide Compounds | TLR1, TLR4, TLR5 | CHRM2 448/4885TDP1 2974/4885L3MBTL1 1787/4885 |
| US-20110105463-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | GPR52, CD22, CD4 | CHRM2 23/4885TDP1 3146/4885L3MBTL1 824/4885 |
| US-20140005418-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | UGT1A6, UGT2B7, UGT1A7 | CHRM2 1696/4885TDP1 4406/4885L3MBTL1 4797/4885 |
| US-20120028971-A1 | OXO-HETEROCYCLICALLY SUBSTITUTED ALKYL CARBOXYLIC ACIDS AND USE THEREOF | AADAC, OTC, HCAR2 | CHRM2 1624/4885TDP1 2877/4885L3MBTL1 3544/4885 |
| US-20040167119-A1 | 2-(aminomethyl) arylamide analgesics | OPRL1, OPRM1, OPRK1 | CHRM2 672/4885TDP1 3650/4885L3MBTL1 2067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.