Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glyburide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 known ✓ | Q09428 | 2/20 | 0.98 |
| ▸ | KCNJ11 known ✓ | Q14654 | 1/20 | 0.98 |
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.98 |
| ▸ | PPARG | P37231 | 2/20 | 0.98 |
| ▸ | MEN1 | O00255 | 1/20 | 0.98 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.98 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.98 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.98 |
| ▸ | MAPT | P10636 | 1/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.98 |
| ▸ | CFTR | P13569 | 1/20 | 0.98 |
| ▸ | TSHR | P16473 | 1/20 | 0.98 |
| ▸ | HTR2A | P28223 | 1/20 | 0.98 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glyburide SCHEMBL15669346 | 0.99 | NLRP3 (1.00) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL22009 | 0.99 | NLRP3 (1.00) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL29355447 | 0.99 | NLRP3 (1.00) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL8497112 | 0.99 | NLRP3 (1.00) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL29669724 | 0.98 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL28807527 | 0.98 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL29010917 | 0.98 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL11354242 | 0.98 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL11351042 | 0.98 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL27818259 | 0.98 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115814029-A | A Chinese and western medicinal composition for treating diabetes | 杨杰 | 2023-03-21 | — | — | CN | claimed |
| CN-117945823-A | Method for preparing sulfenamide by condensing sodium sulfenate and aromatic amine under catalysis of chiral pyridine nitrogen oxide | 河南师范大学 | 2024-04-30 | — | — | CN | disclosed |
| WO-2018193477-A1 | A MEDICAMENT FOR THE TREATMENT OF DISEASES BY BIOFILM FORMING MICROORGANISMS | INDIAN INSTITUTE OF TECHNOLOGY, DELHI (IN) | 2018-10-25 | — | — | WO | disclosed |