Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glyburide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 known ✓ | Q09428 | 2/20 | 1.00 |
| ▸ | KCNJ11 known ✓ | Q14654 | 1/20 | 1.00 |
| ▸ | NLRP3 | Q96P20 | 4/20 | 1.00 |
| ▸ | PPARG | P37231 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | ABCC3 | O15438 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | ABCC9 | O60706 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | CFTR | P13569 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glyburide SCHEMBL8497112 | 1.00 | NLRP3 (1.00) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL15669346 | 1.00 | NLRP3 (1.00) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL29355447 | 1.00 | NLRP3 (1.00) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL28807527 | 0.99 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL29669724 | 0.99 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL29010917 | 0.99 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL11354242 | 0.99 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL11351042 | 0.99 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL20541479 | 0.99 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL27818259 | 0.99 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 58077 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260146195-A1 | SINTERING POWDER | ALPHA ASSEMBLY SOLUTIONS INC. (US) | 2026-05-28 | — | — | US | claimed |
| CN-117126363-B | Filling polyurethane composition, inflation-free tire, and preparation method and application of inflation-free tire | ZHEJIANG HUAFENG NEW MATERIAL Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| US-20260139180-A1 | DEFLOCCULATION ADDITIVES FOR WELLBORE SERVICING FLUID ADDITIVES | HALLIBURTON ENERGY SERVICES INC (US) | 2026-05-21 | — | — | US | claimed |
| CN-122060450-A | Yellowing-resistant UV adhesive and preparation method thereof | 韦尔通科技股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122056884-A | Methods of treating pancreatic cancer | 坎莫森特里克斯公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122037857-A | Yellowing-resistant UV-moisture dual-curing adhesive and preparation method and application thereof | 韦尔通科技股份有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-122040974-A | PCCP pipe faucet seam sealing structure and preparation method thereof | 新疆水发准水建设开发有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-119899352-B | Room-temperature high-efficiency self-repairing aqueous polyurethane elastomer and preparation method and application thereof | 华南理工大学 | 2026-05-12 | — | — | CN | claimed |
| CN-116648251-B | Glibenclamide warp pharmaceutical compositions for nasal administration | 江苏先声药业有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-122010656-A | Application of oxyalkylisourea in introducing methyl and isotopically-labeled methyl | 陕西师范大学 | 2026-05-12 | — | — | CN | claimed |
| EP-0086468-A2 | Oral anti-diabetic preparation | HOECHST UK LIMITED (GB) | 1983-08-24 | — | — | EP | claimed |
| US-4262018-A | CERIUM SALTS OF SULFONYLUREAS | RESEARCH CORPORATION (US) | 1981-04-14 | — | — | US | claimed |
| EP-0007911-A4 | ZINC AND/OR CERIUM CONTAINING SULFONYLUREA HYPOGLYCEMIC AGENTS, PREPARATION AND USE THEREOF. | RESEARCH CORP (US) | 1981-02-25 | — | — | EP | claimed |
| US-4195094-A | Zinc containing hypoglycemic agents | RESEARCH CORPORATION (US) | 1980-03-25 | — | — | US | claimed |
| EP-0007911-A1 | ZINC AND/OR CERIUM CONTAINING SULFONYLUREA HYPOGLYCEMIC AGENTS, PREPARATION AND USE THEREOF | Research Corporation (US) | 1980-02-06 | — | — | EP | claimed |
| WO-1979000435-A1 | ZINC AND/OR CERIUM CONTAINING SULFONYLUREA HYPOGLYCEMIC AGENTS,PREPARATION AND USE THEREOF | RESEARCH CORP (US) | 1979-07-12 | — | — | WO | claimed |
| US-4146613-A | ORAL ANTI-DIABETIC DRUG COMPOSITION | THERA GESELLSCHAFT FUR PATENTVERWERTUNG MBH (DE) | 1979-03-27 | — | — | US | claimed |
| US-4062889-A | Preparation of sulfonylureas | ERIC LUCIEN | 1977-12-13 | — | — | US | claimed |
| US-4060634-A | BLOOD SUGAR LOWERING, NONIONIC SURFACTANT | BOEHRINGER MANNHEIM G.M.B.H. (DT) | 1977-11-29 | — | — | US | claimed |
| US-3979520-A | DIABETES | BOEHRINGER MANNHEIM G.M.B.H. (DT) | 1976-09-07 | — | — | US | claimed |