Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glyburide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 known ✓ | Q09428 | 2/20 | 1.00 |
| ▸ | KCNJ11 known ✓ | Q14654 | 1/20 | 1.00 |
| ▸ | NLRP3 | Q96P20 | 4/20 | 1.00 |
| ▸ | PPARG | P37231 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | ABCC3 | O15438 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | ABCC9 | O60706 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | CFTR | P13569 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glyburide SCHEMBL8497112 | 1.00 | NLRP3 (1.00) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL15669346 | 1.00 | NLRP3 (1.00) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL22009 | 1.00 | NLRP3 (1.00) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL28807527 | 0.99 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL29669724 | 0.99 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL29010917 | 0.99 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL11354242 | 0.99 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL11351042 | 0.99 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL20541479 | 0.99 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 | |
| Glyburide SCHEMBL27818259 | 0.99 | NLRP3 (0.98) | NLRP3ABCC8PPARGMEN1ABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 778 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3608338-B1 | HUMAN ANTIBODIES TO THE GLUCAGON RECEPTOR | REGENERON PHARMA (US) | 2026-03-11 | — | — | EP | claimed |
| EP-3699174-B1 | COMPOSITION FOR PREVENTING OR TREATING TNF-RELATED DISEASES, CONTAINING DERIVATIVE AS ACTIVE INGREDIENT, AND METHOD FOR INHIBITING TNF ACTIVITY BY USING SAME | ILAB (KR) | 2025-11-12 | — | — | EP | claimed |
| EP-3787631-B1 | MODULATORS OF ORPHAN NUCLEAR RECEPTORS FOR NASH AND OTHER METABOLIC DISORDERS | UNIV EMORY (US) | 2025-09-10 | — | — | EP | claimed |
| EP-4135684-B1 | STABLE DIGLYCERIDE EMULSIONS AND METHODS FOR TREATING ORGAN INJURY | UNIV COLUMBIA (US) | 2025-06-18 | — | — | EP | claimed |
| CN-119939915-A | CMC material solid-heat coupling solving method comprising probability model | 南京航空航天大学 | 2025-05-06 | — | — | CN | claimed |
| WO-2025073289-A1 | METHODS OF TREATING DIABETES AND OBESITY | INNOVENT BIOLOGICS (SUZHOU) CO., LTD. (CN) | 2025-04-10 | — | — | WO | claimed |
| CN-119649570-A | Chain track deformation monitoring system and operation method | 湖南华菱湘潭钢铁有限公司 | 2025-03-18 | — | — | CN | claimed |
| EP-3988123-B1 | ANTIBODY-COUPLED CYCLIC PEPTIDE TYROSINE TYROSINE COMPOUNDS AS MODULATORS OF NEUROPEPTIDE Y RECEPTORS | JANSSEN PHARMACEUTICA NV (BE) | 2025-02-26 | — | — | EP | claimed |
| CN-119342431-A | Underground fusion networking private network operation system | 国家能源集团乌海能源有限责任公司 | 2025-01-21 | — | — | CN | claimed |
| EP-3375452-B1 | USE OF LAMBDA INTERFERONS IN THE TREATMENT OF AN OBESITY-RELATED DISORDER, ATHEROSCLEROSIS OR A COAGULATION DISORDER | ANDREAKOS EVANGELOS (GR) | 2025-01-08 | — | — | EP | claimed |
| CN-112291785-B | Reward method and device | 中国联合网络通信集团有限公司 | 2022-07-22 | — | — | CN | claimed |
| EP-3302514-B1 | METHODS OF REDUCING OR PREVENTING INTIMAL DAMAGE CAUSED BY MECHANICAL STIMULATION OF ENDOTHELIAL CELLS | UNIV MARYLAND (US) | 2022-07-06 | — | — | EP | claimed |
| CN-216775242-U | Little basic station heat radiation structure of intelligence lamp pole | 城市智能通讯科技(山东)有限公司 | 2022-06-17 | — | — | CN | claimed |
| EP-1931320-B1 | MICROPARTICLES WITH MODIFIED RELEASE OF AT LEAST ONE ACTIVE PRINCIPLE AND ORAL DOSAGE FORM COMPRISING THE SAME | FLAMEL IRELAND LTD (IE) | 2022-06-15 | — | — | EP | claimed |
| EP-3448435-B1 | PROTEIN BASED EXCIPIENT FOR ACTIVE PHARMACEUTICAL INGREDIENTS | ROUSSELOT B V (NL) | 2022-06-01 | — | — | EP | claimed |
| EP-3753966-B1 | AMPHIPHILIC BLOCK COPOLYMER, PREPARATION METHOD THEREOF AND NANOMICELLE DRUG-LOADING SYSTEM | SHANGHAI BEST LINK BIOSCIENCE LLC (CN) | 2022-05-25 | — | — | EP | claimed |
| EP-3999043-A1 | PREPARATION OF LIPOPHILIC ACTIVE INGREDIENTS | SPI Pharma, INC. (US) | 2022-05-25 | — | — | EP | claimed |
| CN-114245448-A | Power distribution method for electric power 5G micro base station | 国网福建省电力有限公司漳州供电公司 | 2022-03-25 | — | — | CN | claimed |
| EP-3411026-B1 | USE OF STIMULATORS OF SOLUBLE GUANYLATE CYCLASE FOR THE TREATMENT OF NONALCOHOLIC STEATOHEPATITIS (NASH) | CYCLERION THERAPEUTICS INC (US) | 2022-03-09 | — | — | EP | claimed |
| CN-112563741-B | Dual-frequency dual-polarization micro base station antenna suitable for 5G full frequency band and dual-antenna system | 东南大学 | 2022-03-08 | — | — | CN | claimed |