Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.74 |
| ▸ | HPGD | P15428 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 4/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.73 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.73 |
| ▸ | FLT3 | P36888 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | PTPRC | P08575 | 1/20 | 0.70 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.70 |
| ▸ | PTPRB | P23467 | 1/20 | 0.70 |
| ▸ | PTPRE | P23469 | 1/20 | 0.70 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.70 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3918254 | 0.98 | MEN1 (0.75) | ALDH1A1HPGDSMN1; SMN2MAPTMEN1 | |
| SCHEMBL20541948 | 0.95 | KDM4E (0.75) | ALDH1A1HPGDSMN1; SMN2MAPTMEN1 | |
| SCHEMBL8289718 | 0.86 | FLT3 (0.97) | ALDH1A1HPGDSMN1; SMN2MAPTMEN1 | |
| SCHEMBL22435152 | 0.85 | PTPN1 (0.77) | ALDH1A1HPGDSMN1; SMN2MAPTMEN1 | |
| SCHEMBL30764986 | 0.84 | PTPN1 (0.73) | ALDH1A1HPGDSMN1; SMN2MAPTMEN1 | |
| SCHEMBL3914847 | 0.84 | FLT3 (1.00) | ALDH1A1HPGDSMN1; SMN2MAPTMEN1 | |
| SCHEMBL20541804 | 0.84 | FLT3 (0.75) | ALDH1A1HPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL10628409 | 0.83 | PTPN1 (0.68) | ALDH1A1HPGDSMN1; SMN2MAPTMEN1 | |
| SCHEMBL5370842 | 0.83 | ALDH1A1 (1.00) | ALDH1A1HPGDSMN1; SMN2MAPTMEN1 | |
| SCHEMBL5837972 | 0.83 | PTPN1 (1.00) | ALDH1A1HPGDSMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200123128-A1 | SUBSTITUTED 2-ACYLAMINO-CYCLOALKYLTHIOPHENE-3-CARBOXYLIC ACID ARYLAMIDES AS INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNEL TMEM16A | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-04-23 | — | — | US | claimed |
| EP-3612180-A1 | SUBSTITUTED 2-ACYLAMINO-CYCLOALKYLTHIOPHENE-3-CARBOXYLIC ACID ARYLAMIDES AS INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNEL TMEM16A | The Regents of the University of California (US) | 2020-02-26 | — | — | EP | claimed |
| WO-2018195127-A1 | SUBSTITUTED 2-ACYLAMINO-CYCLOAKYLTHIOPHENE-3-CARBOXYLIC ACID ARYLAMIDES AS INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNEL TMEM16A | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-10-25 | — | — | WO | claimed |
| EP-3612180-B1 | SUBSTITUTED 2-ACYLAMINO-CYCLOALKYLTHIOPHENE-3-CARBOXYLIC ACID ARYLAMIDES AS INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNEL TMEM16A | UNIV CALIFORNIA (US) | 2023-10-11 | — | — | EP | disclosed |
| US-11358947-B2 | Substituted 2-acylamino-cycloalkylthiophene-3-carboxylic acid arylamides as inhibitors of calcium-activated chloride channel TMEM16A | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-06-14 | — | — | US | disclosed |
| US-20200123128-A1 | SUBSTITUTED 2-ACYLAMINO-CYCLOALKYLTHIOPHENE-3-CARBOXYLIC ACID ARYLAMIDES AS INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNEL TMEM16A | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-04-23 | — | — | US | disclosed |
| EP-3612180-A1 | SUBSTITUTED 2-ACYLAMINO-CYCLOALKYLTHIOPHENE-3-CARBOXYLIC ACID ARYLAMIDES AS INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNEL TMEM16A | The Regents of the University of California (US) | 2020-02-26 | — | — | EP | disclosed |
| WO-2018195127-A1 | SUBSTITUTED 2-ACYLAMINO-CYCLOAKYLTHIOPHENE-3-CARBOXYLIC ACID ARYLAMIDES AS INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNEL TMEM16A | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11358947-B2 | Substituted 2-acylamino-cycloalkylthiophene-3-carboxylic acid arylamides as inhibitors of calcium-activated chloride channel TMEM16A | TMEM161A, ANO2, TRPV6 | ALDH1A1 1043/4885HPGD 2067/4885SMN1; SMN2 3477/4885 |
| US-20200123128-A1 | SUBSTITUTED 2-ACYLAMINO-CYCLOALKYLTHIOPHENE-3-CARBOXYLIC ACID ARYLAMIDES AS INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNEL TMEM16A | TMEM161A, ANO2, TRPV6 | ALDH1A1 1043/4885HPGD 2067/4885SMN1; SMN2 3477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.