Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA known ✓ | P35790 | 9/20 | 0.42 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2464589 | 0.97 | ALDH1A1 (0.51) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Bromide SCHEMBL7297527 | 0.90 | ALDH1A1 (0.58) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Bromide SCHEMBL11309227 | 0.83 | CHKA (0.53) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| SCHEMBL4339091 | 0.83 | ALDH1A1 (0.61) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Hydrochloric Acid SCHEMBL2467678 | 0.81 | ALDH1A1 (0.64) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| SCHEMBL4356760 | 0.81 | CHKA (0.52) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| Bromide SCHEMBL10597082 | 0.81 | MMP3 (0.45) | ALDH1A1MAOBMAOA | |
| Hydrochloric Acid SCHEMBL11602629 | 0.80 | ALDH1A1 (0.51) | ALDH1A1KDM4ERAB9ACHKALMNA | |
| SCHEMBL4325064 | 0.79 | MMP3 (0.46) | ALDH1A1MAOBMAOA | |
| Bromide SCHEMBL20544131 | 0.79 | CYP2A6 (0.43) | ALDH1A1KDM4ERAB9ALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180371310-A1 | DYNAMIC RESPONSE COMPONENTS WITH AESTHETIC PROPERTIES | FUNDACIÓN CIDETEC (ES) | 2018-12-27 | — | — | US | disclosed |
| EP-3395927-A1 | DYNAMIC RESPONSE COMPONENTS WITH AESTHETIC PROPERTIES | Fundacion Cidetec (ES) | 2018-10-31 | — | — | EP | disclosed |