Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 6/20 | 0.53 |
| ▸ | GABBR1 | Q9UBS5 | 6/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PHGDH | O43175 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20544752 | 0.86 | UTS2R (0.48) | GABBR2GABBR1LMNACYP2C9CYP1A2 | |
| SCHEMBL21979535 | 0.84 | KDM4E (0.47) | GABBR2GABBR1LMNACYP2C9CYP2D6 | |
| SCHEMBL21979517 | 0.84 | KDM4E (0.47) | GABBR2GABBR1LMNACYP2C9CYP2D6 | |
| SCHEMBL8514238 | 0.84 | KDM4E (0.47) | GABBR2GABBR1LMNACYP2C9CYP2D6 | |
| SCHEMBL115980 | 0.83 | ROCK1 (0.55) | GABBR2GABBR1PHGDHKCNH2SCN5A | |
| SCHEMBL4598191 | 0.83 | ROCK1 (0.55) | GABBR2GABBR1PHGDHKCNH2SCN5A | |
| SCHEMBL20545427 | 0.83 | DCAF1 (0.51) | GABBR2GABBR1LMNACYP2C9CYP1A2 | |
| SCHEMBL22805483 | 0.82 | CNR2 (0.44) | GABBR2GABBR1KDM4ECNR2 | |
| Hydrochloric Acid SCHEMBL7973435 | 0.81 | RPS6KA5 (0.54) | GABBR2GABBR1KCNH2SCN5A | |
| SCHEMBL20544814 | 0.81 | GABBR2 (0.44) | GABBR2GABBR1LMNACYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180312516-A1 | Protein Kinase B Inhibitors | ASTRAZENECA AB (SE) | 2018-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312516-A1 | Protein Kinase B Inhibitors | PRKAR2B, PRKCB, AKT1 | GABBR2 2327/4885GABBR1 3042/4885LMNA 1518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.