SCHEMBL4598191

SCHEMBL4598191

NC[C@H](NC(=O)O)c1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK1 Q13464 3/20 0.55
RPS6KA5 O75582 2/20 0.55
AKT1 P31749 2/20 0.55
GSK3B P49841 2/20 0.55
NEK4 P51957 2/20 0.55
PRKCD Q05655 2/20 0.55
PRKG2 Q13237 2/20 0.55
PRKG1 Q13976 2/20 0.55
PKN2 Q16513 2/20 0.55
CLK4 Q9HAZ1 2/20 0.55
ROCK2 O75116 2/20 0.55
MAPK13 O15264 1/20 0.55
DYRK3 O43781 1/20 0.55
PRKD3 O94806 1/20 0.55
MAP4K4 O95819 1/20 0.55
CHEK2 O96017 1/20 0.55
PRKCG P05129 1/20 0.55
CDK1 P06493 1/20 0.55
PIM1 P11309 1/20 0.55
RPS6KB1 P23443 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL115980 1.00 ROCK1 (0.55) ROCK1RPS6KA5AKT1GSK3BNEK4
Hydrochloric Acid SCHEMBL7973435 0.98 RPS6KA5 (0.54) ROCK1RPS6KA5AKT1GSK3BNEK4
SCHEMBL8652164 0.86 RPS6KA5 (0.54) ROCK1RPS6KA5AKT1GSK3BNEK4
SCHEMBL7433148 0.85 RPS6KA5 (0.52) ROCK1RPS6KA5AKT1GSK3BNEK4
SCHEMBL5672684 0.85 RPS6KA5 (0.52) ROCK1RPS6KA5AKT1GSK3BNEK4
SCHEMBL10323207 0.85 HRH1 (0.50) ROCK1RPS6KA5AKT1GSK3BNEK4
SCHEMBL21268612 0.84 ALDH1A1 (0.45) ROCK1RPS6KA5AKT1GSK3BNEK4
SCHEMBL10707471 0.84 ALDH1A1 (0.45) ROCK1RPS6KA5AKT1GSK3BNEK4
SCHEMBL20544796 0.83 GABBR2 (0.53) GABBR2GABBR1KCNH2SCN5APHGDH
SCHEMBL22805483 0.83 CNR2 (0.44) ROCK1RPS6KA5AKT1GSK3BNEK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3365324-A1 SYNTHESIS OF CYCLOHEXANE CARBOXAMIDE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS The Procter and Gamble Company (US) 2018-08-29 EP disclosed
WO-2017070418-A1 SYNTHESIS OF CYCLOHEXANE CARBOXAMIDE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS THE PROCTER & GAMBLE COMPANY (US) 2017-04-27 WO disclosed
EP-1924265-A2 CHEMOKINE RECEPTOR BINDING COMPOUNDS Genzyme Corporation (US) 2008-05-28 EP disclosed
WO-2007022371-A2 CHEMOKINE RECEPTOR BINDING COMPOUNDS GENZYME CORPORATION (US) 2007-02-22 WO disclosed