Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | PGK1 | P00558 | 2/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25410559 | 0.78 | CHRNB2 (0.44) | CHRNB2CHRNA4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL27759682 | 0.77 | CHRNB2 (0.43) | CHRNB2CHRNA4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL13928210 | 0.77 | CHRNB2 (0.43) | CHRNB2CHRNA4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL28163866 | 0.75 | FYN (0.42) | ALDH1A1MEN1KMT2ACYP2C19 | |
| SCHEMBL31168643 | 0.75 | CHRNB2 (0.42) | CHRNB2CHRNA4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL29764952 | 0.75 | CHRNB2 (0.42) | CHRNB2CHRNA4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL114842 | 0.75 | CHRNB2 (0.42) | CHRNB2CHRNA4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7412305 | 0.75 | CYP3A4 (0.45) | CHRNB2CHRNA4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL608749 | 0.75 | CHRNB2 (0.42) | CHRNB2CHRNA4ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2122632 | 0.75 | CHRNB2 (0.42) | CHRNB2CHRNA4ALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11077098-B2 | Opioid receptor ligands and methods of using and making same | TREVENA, INC. (US) | 2021-08-03 | — | — | US | disclosed |
| US-20180311222-A1 | Opioid Receptor Ligands And Methods Of Using And Making Same | TREVENA, INC. | 2018-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180311222-A1 | Opioid Receptor Ligands And Methods Of Using And Making Same | OPRL1, OPRK1, OPRM1 | CHRNB2 127/4885CHRNA4 104/4885ALDH1A1 1225/4885 |
| US-11077098-B2 | Opioid receptor ligands and methods of using and making same | OPRL1, OPRK1, OPRM1 | CHRNB2 127/4885CHRNA4 104/4885ALDH1A1 1225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.