Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.69 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.44 |
| ▸ | SCN1A | P35498 | 2/20 | 0.44 |
| ▸ | SCN4A | P35499 | 2/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.44 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | SCN11A | Q9UI33 | 1/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1552771 | 1.00 | CYP19A1 (0.69) | CYP19A1CACNA1FSCN1ASCN4ACACNA1D | |
| SCHEMBL26664974 | 1.00 | CYP19A1 (0.69) | CYP19A1CACNA1FSCN1ASCN4ACACNA1D | |
| SCHEMBL15196027 | 1.00 | CYP19A1 (0.69) | CYP19A1CACNA1FSCN1ASCN4ACACNA1D | |
| SCHEMBL14520901 | 0.83 | CYP19A1 (0.72) | CYP19A1KCNH2MAOBMAOACXCR3 | |
| SCHEMBL4556388 | 0.83 | CYP19A1 (0.72) | CYP19A1KCNH2MAOBMAOACXCR3 | |
| SCHEMBL10530071 | 0.81 | CYP19A1 (1.00) | CYP19A1ALDH1A1 | |
| SCHEMBL8245665 | 0.81 | CYP19A1 (0.70) | CYP19A1MMP2MMP9KDM1ACXCR3 | |
| SCHEMBL22623727 | 0.81 | CYP19A1 (1.00) | CYP19A1ALDH1A1 | |
| SCHEMBL10530941 | 0.81 | CYP19A1 (1.00) | CYP19A1ALDH1A1 | |
| SCHEMBL13201868 | 0.81 | CYP19A1 (0.70) | CYP19A1MMP2MMP9KDM1ACXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222266-B2 | Azabicyclo [3.1.0] hexyl derivatives as modulators of dopamine D3 receptors | GLAXO GROUP LIMITED (GB) | 2012-07-17 | — | — | US | disclosed |
| US-8163927-B2 | Azabicyclo [3.1.0] hexane derivatives as modulators of dopamine D3 receptors | GLAXO GROUP LIMITED (GB) | 2012-04-24 | — | — | US | disclosed |
| US-7727988-B2 | Azabicyclo[3.1.0]hex-3-yl}alkyl)pyrimidinedione | GLAXO GROUP LIMITED (GB) | 2010-06-01 | — | — | US | disclosed |
| US-20100069416-A1 | Azabicyclo [3.1.0] Hexyl Derivatives as Modulators of Dopamine D3 Receptors | GLAXO GROUP LIMITED | 2010-03-18 | — | — | US | disclosed |
| US-20100063097-A1 | Azabicyclo [3.1.0] Hexane Derivatives as Modulators of Dopamine D3 Receptors | GLAXO GROUP LIMITED | 2010-03-11 | — | — | US | disclosed |
| US-20070249642-A1 | Azabicyclo[3.1.0]hex-3-yl}alkyl)pyrimidinedione | GLAXO GROUP LIMITED (GB) | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069416-A1 | Azabicyclo [3.1.0] Hexyl Derivatives as Modulators of Dopamine D3 Receptors | DRD3, DRD2, HTR3A | CYP19A1 503/4885CACNA1F 2067/4885SCN1A 2009/4885 |
| US-20070249642-A1 | Azabicyclo[3.1.0]hex-3-yl}alkyl)pyrimidinedione | AZI2, NT5C3B, CYP1B1 | CYP19A1 1558/4885CACNA1F 1296/4885SCN1A 864/4885 |
| US-20100063097-A1 | Azabicyclo [3.1.0] Hexane Derivatives as Modulators of Dopamine D3 Receptors | DRD3, DRD2, DRD1 | CYP19A1 270/4885CACNA1F 1852/4885SCN1A 2328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.