Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 4/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.43 |
| ▸ | LATS1 | O95835 | 8/20 | 0.43 |
| ▸ | LATS2 | Q9NRM7 | 6/20 | 0.41 |
| ▸ | F7 | P08709 | 2/20 | 0.39 |
| ▸ | F3 | P13726 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31375158 | 0.80 | LATS1 (0.60) | LATS1LATS2F7F3ACHE | |
| SCHEMBL4251618 | 0.77 | ACHE (0.45) | LATS1LATS2ACHENR4A2KDM4E | |
| SCHEMBL4848530 | 0.76 | GABRA1 (0.40) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL20547835 | 0.76 | MAP4K4 (0.52) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL4246335 | 0.74 | ACHE (0.70) | LATS1LATS2ACHEKDM4EPOLB | |
| SCHEMBL29650635 | 0.73 | LATS1 (0.56) | LATS1LATS2ACHE | |
| SCHEMBL31375899 | 0.73 | LATS1 (0.59) | LATS1LATS2ACHEKDM4EPOLB | |
| SCHEMBL30444888 | 0.70 | GABRG2 (0.50) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL32667309 | 0.70 | GABRG2 (0.47) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| Ammonia Solution, Strong SCHEMBL16037372 | 0.69 | GABRG2 (0.49) | GABRG2GABRB3GABRA5GABRA3GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3615537-A2 | 6-6 FUSED BICYCLIC HETEROARYL COMPOUNDS AND THEIR USE AS LATS INHIBITORS | Novartis AG (CH) | 2020-03-04 | — | — | EP | disclosed |
| WO-2018198077-A2 | 6-6 FUSED BICYCLIC HETEROARYL COMPOUNDS AND THEIR USE AS LATS INHIBITORS | NOVARTIS AG (CH) | 2018-11-01 | — | — | WO | disclosed |