⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15747660 | 0.83 | — | — | |
| SCHEMBL536664 | 0.81 | CHUK (0.34) | — | |
| SCHEMBL13714814 | 0.80 | — | — | |
| SCHEMBL6791945 | 0.79 | MEN1 (0.33) | — | |
| SCHEMBL12495984 | 0.79 | PDE10A (0.35) | — | |
| SCHEMBL8109272 | 0.78 | L3MBTL1 (0.45) | — | |
| SCHEMBL4087492 | 0.76 | ALDH1A1 (0.35) | — | |
| SCHEMBL28483907 | 0.76 | — | — | |
| SCHEMBL7096119 | 0.74 | ALDH1A1 (0.42) | — | |
| SCHEMBL12495475 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730298-B1 | SPECIFIC SUBSTRATES FOR O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | EPFL ECOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (CH) | 2015-11-11 | — | — | EP | disclosed |
| US-8163479-B2 | Specific substrates for O6-alkylguanine-DNA alkyltransferase | ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) | 2012-04-24 | — | — | US | disclosed |
| EP-1857458-A1 | Process for the preparation of abacavir | SOLMAG S.p.A. (IT) | 2007-11-21 | — | — | EP | disclosed |
| US-20070243568-A1 | Specific Substrates for O6-Alkylguanine-Dna Alkyltransferase | EPFL ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (CH) | 2007-10-18 | — | — | US | disclosed |
| US-6870053-B2 | Chloropyrimidine intermediates | SMITHKLINE BEECHAM CORPORATION (US) | 2005-03-22 | — | — | US | disclosed |
| US-20030187263-A1 | Chloropvrimidine intermediates | SMITHKLINE BEECHAM CORPORATION | 2003-10-02 | — | — | US | disclosed |
| US-6555687-B1 | N,N'-(4,6-dichloro-2,5-pyrimidinediyl)bisformamide as a chemical intermediate for 9-substituted-2-aminopurines, such as famciclovir and penciclovir; viricides; HIV and hepatitus virus | SMITHKLINE BEECHAM CORPORATION | 2003-04-29 | — | — | US | disclosed |
| US-6552193-B1 | N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide | SMITHKLINE BEECHAM CORPORATION | 2003-04-22 | — | — | US | disclosed |
| EP-1013647-B1 | Process for the preparation of N-(amino-4,6-dihalogenopyrimidin)-formamides | LONZA AG (CH) | 2002-11-27 | — | — | EP | disclosed |
| US-20020173649-A1 | Chloropvrimidine intermediates | SMITHKLINE BEECHAM CORPORATION | 2002-11-21 | — | — | US | disclosed |
| US-5055458-A | PURINE DERIVATIVES HAVING ANTIVIRAL ACTIVITY | BEECHAM GROUP P.L.C. (GB) | 1991-10-08 | — | — | US | disclosed |
| EP-0413544-A2 | Purine derivatives, process for their preparation, pharmaceutical compositions and intermediates | Beecham Group p.l.c. (GB) | 1991-02-20 | — | — | EP | disclosed |
| EP-0404296-A1 | Phosphono derivatives of purine with antiviral activity | Beecham Group p.l.c. (GB) | 1990-12-27 | — | — | EP | disclosed |
| EP-0399743-A1 | Phosphonomethylthio-alkoseypureine derivatives, intermediate products for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1990-11-28 | — | — | EP | disclosed |
| US-4965270-A | Viricides | BEECHAM GROUP P.L.C. (GB) | 1990-10-23 | — | — | US | disclosed |
| US-4910307-A | Process for preparing purines | BEECHAM GROUP P.L.C. (GB) | 1990-03-20 | — | — | US | disclosed |
| EP-0353955-A2 | Novel compounds | BEECHAM GROUP PLC (GB) | 1990-02-07 | — | — | EP | disclosed |
| EP-0319228-A2 | Novel compounds | BEECHAM GROUP PLC (GB) | 1989-06-07 | — | — | EP | disclosed |
| EP-0294069-A2 | Purine compounds, process for their preparation, intermediates and pharmaceutical compositions | BEECHAM GROUP PLC (GB) | 1988-12-07 | — | — | EP | disclosed |
| EP-0242482-A2 | Antiviral purine derivatives and process for their preparation | BEECHAM GROUP PLC (GB) | 1987-10-28 | — | — | EP | disclosed |