Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20550694 | 0.82 | ALDH1A1 (0.52) | ALDH1A1LMNAHTTNPSR1KCNH2 | |
| SCHEMBL20550293 | 0.80 | CDK4 (0.54) | ALDH1A1LMNACLK4SMN1; SMN2NPC1 | |
| SCHEMBL20550274 | 0.80 | COMT (0.41) | ALDH1A1LMNANPSR1KCNH2HRH3 | |
| SCHEMBL1679855 | 0.80 | CYP3A4 (0.49) | ALDH1A1LMNAHTTNPSR1KCNH2 | |
| SCHEMBL20550291 | 0.79 | CDK2 (0.46) | COMT | |
| SCHEMBL12279254 | 0.78 | KCNH2 (0.41) | ALDH1A1LMNAHTTNPSR1KCNH2 | |
| SCHEMBL20550693 | 0.78 | KDM4E (0.40) | ALDH1A1LMNANPSR1SMN1; SMN2NPC1 | |
| SCHEMBL20550428 | 0.78 | CDK2 (0.41) | RAB9AKDM4ECOMTL3MBTL1 | |
| SCHEMBL12278345 | 0.77 | CYP3A4 (0.46) | ALDH1A1LMNAHTTNPSR1KCNH2 | |
| SCHEMBL20550442 | 0.77 | COMT (0.39) | ALDH1A1LMNAPPARASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10414759-B2 | Phenylthiazoles and uses thereof | PURDUE RESEARCH FOUNDATION (US) | 2019-09-17 | — | — | US | disclosed |
| US-20180319784-A1 | PHENYLTHIAZOLES AND USES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2018-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180319784-A1 | PHENYLTHIAZOLES AND USES THEREOF | TPMT, TST, CLPP | ALDH1A1 2016/4885LMNA 4725/4885HTT 2765/4885 |
| US-10414759-B2 | Phenylthiazoles and uses thereof | TPMT, TST, CLPP | ALDH1A1 1901/4885LMNA 4733/4885HTT 3052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.