Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 11/20 | 0.39 |
| ▸ | CDK4 | P11802 | 10/20 | 0.39 |
| ▸ | CDK7 | P50613 | 7/20 | 0.39 |
| ▸ | AURKA | O14965 | 7/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.39 |
| ▸ | CDK1 | P06493 | 6/20 | 0.39 |
| ▸ | WEE1 | P30291 | 3/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 6/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.38 |
| ▸ | CCND1 | P24385 | 4/20 | 0.38 |
| ▸ | CCND3 | P30281 | 4/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.38 |
| ▸ | CCNH | P51946 | 2/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20550266 | 0.93 | PIK3CA (0.41) | CDK2CCNE1CDK9CDK4CDK7 | |
| SCHEMBL20550444 | 0.90 | CDK2 (0.45) | CDK2CCNE1CDK9CDK4CDK7 | |
| SCHEMBL20550302 | 0.84 | CDK2 (0.43) | CDK2CCNE1CDK9CDK4CDK7 | |
| SCHEMBL20550307 | 0.84 | CDK2 (0.43) | CDK2CCNE1CDK9CDK4CDK7 | |
| SCHEMBL20550699 | 0.82 | CDK2 (0.41) | CDK2CCNE1CDK9CDK4CDK7 | |
| SCHEMBL20550439 | 0.81 | PIK3CA (0.35) | CDK2CCNE1CDK9CDK4CDK7 | |
| SCHEMBL20550303 | 0.80 | CDK2 (0.46) | CDK2CCNE1CDK9CDK4CDK7 | |
| SCHEMBL20550275 | 0.80 | CDK2 (0.48) | CDK2CCNE1CDK9CDK4CDK7 | |
| SCHEMBL20550435 | 0.79 | CDK2 (0.39) | CDK2CDK9CDK4CDK7AURKA | |
| SCHEMBL20550434 | 0.77 | CDK4 (0.50) | CDK2CCNE1CDK9CDK4CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10414759-B2 | Phenylthiazoles and uses thereof | PURDUE RESEARCH FOUNDATION (US) | 2019-09-17 | — | — | US | disclosed |
| US-20180319784-A1 | PHENYLTHIAZOLES AND USES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2018-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180319784-A1 | PHENYLTHIAZOLES AND USES THEREOF | TPMT, TST, CLPP | CDK2 3199/4885CCNE1 3849/4885CDK9 3771/4885 |
| US-10414759-B2 | Phenylthiazoles and uses thereof | TPMT, TST, CLPP | CDK2 3101/4885CCNE1 3790/4885CDK9 3671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.