Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.35 |
| ▸ | CDK2 | P24941 | 5/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 4/20 | 0.33 |
| ▸ | AURKA | O14965 | 3/20 | 0.33 |
| ▸ | CDK4 | P11802 | 3/20 | 0.33 |
| ▸ | CDK7 | P50613 | 3/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20550264 | 0.93 | KDM4E (0.38) | PIK3CACDK2CCNE1PIK3CDPIK3CB | |
| SCHEMBL20550443 | 0.90 | CNR1 (0.38) | PIK3CACDK2CCNE1PIK3CDPIK3CB | |
| SCHEMBL20550437 | 0.81 | CDK2 (0.43) | PIK3CACDK2CCNE1PIK3CDPIK3CB | |
| SCHEMBL20550441 | 0.81 | RAB9A (0.38) | CDK2CCNE1KDM4ERAB9AGLA | |
| SCHEMBL20550300 | 0.73 | CDK4 (0.58) | CDK2CCNE1KDM4ERAB9AGLA | |
| SCHEMBL20550262 | 0.72 | TNF (0.39) | PIK3CACDK2CCNE1PIK3CDPIK3CB | |
| SCHEMBL20550307 | 0.72 | CDK2 (0.43) | PIK3CACDK2CCNE1PIK3CDPIK3CB | |
| SCHEMBL20550303 | 0.71 | CDK2 (0.46) | CDK2CCNE1KDM4ERAB9AGLA | |
| SCHEMBL20550275 | 0.70 | CDK2 (0.48) | CDK2CCNE1KDM4ERAB9AGLA | |
| SCHEMBL20550270 | 0.70 | TNF (0.43) | CDK2CCNE1KDM4ERAB9AGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10414759-B2 | Phenylthiazoles and uses thereof | PURDUE RESEARCH FOUNDATION (US) | 2019-09-17 | — | — | US | disclosed |
| US-20180319784-A1 | PHENYLTHIAZOLES AND USES THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2018-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180319784-A1 | PHENYLTHIAZOLES AND USES THEREOF | TPMT, TST, CLPP | PIK3CA 2946/4885CDK2 3199/4885CCNE1 3849/4885 |
| US-10414759-B2 | Phenylthiazoles and uses thereof | TPMT, TST, CLPP | PIK3CA 2862/4885CDK2 3101/4885CCNE1 3790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.